March 28 with Eric Bankaitis
Presented by Eric Bankaitis
Graduate Student- Chris Wright Lab
Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair.
Xiong et al. – 2013 Developmental Cell; 25 pages 169-181 http://www.sciencedirect.com/science/article/pii/S153458071300186X?via=ihub
Experimental models of tissue-tissue interactions that guide cyclical homeostasis and/or acute regeneration are emerging in complex mammalian systems. Understanding the molecular circuitry for stepwise, often inter-dependent, interactions within “tissue units” will help to address developmental and pathological disorders. Xiong et. al. identify Brg1 (part of the BAF chromatin-remodeling complex) as mediator and activator of Shh signals guiding hair follicle growth and regeneration. Brg1 and Shh enlist the transcription factors NF-kB or Gli, respectively, in different cellular domains of the hair growth/regeneration cycle. The study demonstrates how chromatin remodeling, transcriptional regulation, and intercellular signaling are integrated to control stem cells during tissue regeneration.