I am fascinated by the development, function and adaptability of the nervous system. My research focuses on the genetic mechanisms underlying coordinated movement, behavior and cognition. How does nervous system circuitry underlying behavior develop? How are nervous system circuits modified by experience? How do these mechanisms go awry in inherited neurological diseases and age-related neurological decline? These questions center around the common themes of information transfer and information storage in cells of the nervous system. My long-term focus has been on the intercellular synapses that establish and provide communication between nerve cells.
The Broadie Lab works on nervous system development, including neuronal pathfinding, target recognition and synaptogenesis. Lab members take a genetic approach in Drosophila, using mutagenesis screens to identify developmental mutants, and a combination of light imaging, electron microscope ultrastructural studies and electrophysiology to characterize mutant phenotypes. Trainees in the Broadie lab typically take one of two courses; 1) molecular genetics training in the mutagenesis, mapping, cloning and transgenic manipulation of target genes, or 2) cellular neurobiology training in confocal imaging and functional neurobiological techniques to assay mutant phenotypes. Motivated students pursue both courses in parallel.
Figure 3. Secreted MTG resides within the synaptic matrix environment. Excerpted from "Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments".
Postdoctoral Positions Available
WE ARE VERY ACTIVELY RECRUITING POSTDOCTORAL RESEARCHERS! We are interested in recruiting cellular and molecular biologists interested in neurobiology, particularly synaptic biology. We are particularly keen to recruit experienced electrophysiologists (patch-clamp, TEVC) and confocal microscopists (live imaging, optogenetics). We are also looking for molecular geneticists with experience in Drosophila or other genetic models (yeast, C. elegans, zebrafish).
We use genetic approaches to study the nervous system, particularly the development, function and plasticity of neuronal synapses. We model many human diseases which involve synaptic dysfunction, including Fragile X syndrome. We use a multidisciplinary approach coupling molecular genetics with neurological techniques including electrophysiology, optical imaging and EM.
If you have an interest, please contact me directly at firstname.lastname@example.org. All inquiries should be accompanied by a CV and statement of specific interests.