{"id":339,"date":"2014-03-25T00:00:00","date_gmt":"2014-03-25T00:00:00","guid":{"rendered":"https:\/\/medschool.prd.vanderbilt.edu\/pdb\/2014\/03\/25\/march-28-with-eric-bankaitis\/"},"modified":"2014-03-25T00:00:00","modified_gmt":"2014-03-25T00:00:00","slug":"march-28-with-eric-bankaitis","status":"publish","type":"post","link":"https:\/\/medschool.vanderbilt.edu\/pdb\/2014\/03\/25\/march-28-with-eric-bankaitis\/","title":{"rendered":"March 28 with Eric Bankaitis"},"content":{"rendered":"<p>Presented by&nbsp;Eric Bankaitis&nbsp;<\/p>\n<p>Graduate Student- Chris Wright Lab<\/p>\n<p>Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair.<\/p>\n<p>Xiong et al. &ndash; 2013 Developmental Cell; 25 pages 169-181 &nbsp;http:\/\/www.sciencedirect.com\/science\/article\/pii\/S153458071300186X?via=ihub&nbsp;<\/p>\n<p><img decoding=\"async\" alt=\"Untitled-2 copy copy.jpg\" src=\"\/wp-content\/uploads\/sites\/46\/public_files\/Untitled-2%20copy%20copy.jpg\" style=\"width: 502px; height: 290px; float: right;\" \/>Experimental models of tissue-tissue interactions that guide cyclical homeostasis and\/or acute regeneration are emerging in complex mammalian systems.&nbsp; Understanding the molecular circuitry for stepwise, often inter-dependent, interactions within &ldquo;tissue units&rdquo; will help to address developmental and pathological disorders.&nbsp; Xiong et. al. identify Brg1 (part of the BAF chromatin-remodeling complex) as mediator and activator of Shh signals guiding hair follicle growth and regeneration.&nbsp; Brg1 and Shh enlist the transcription factors NF-kB or Gli, respectively, in different cellular domains of the hair growth\/regeneration cycle.&nbsp; The study demonstrates how chromatin remodeling, transcriptional regulation, and intercellular signaling are integrated to control stem cells during tissue regeneration.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Presented by&nbsp;Eric Bankaitis&nbsp; Graduate Student- Chris Wright Lab Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair. Xiong et al. &ndash; 2013 Developmental Cell; 25 pages 169-181 &nbsp;http:\/\/www.sciencedirect.com\/science\/article\/pii\/S153458071300186X?via=ihub&nbsp; Experimental models of tissue-tissue interactions that guide cyclical homeostasis and\/or acute regeneration are emerging in complex mammalian systems.&nbsp; Understanding the molecular&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_links_to":"","_links_to_target":""},"categories":[],"tags":[],"class_list":["post-339","post","type-post","status-publish","format-standard","hentry"],"acf":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paxki9-5t","_links":{"self":[{"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/posts\/339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/comments?post=339"}],"version-history":[{"count":0,"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/posts\/339\/revisions"}],"wp:attachment":[{"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/media?parent=339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/categories?post=339"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/pdb\/wp-json\/wp\/v2\/tags?post=339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}