Drug Discovery

Shaun Stauffer, Ph.D.

Research Assistant Professor of Pharmacology

Research Description

Dr. Stauffer's research interests lie in the areas of allosteric modulation of cell surface receptors, protein-protein interaction (PPI) modulation, and protease structure-based inhibitor design towards the development of novel therapeutics and selective probe tool compounds.

In addition, Dr. Stauffer is interested in catalysis and reaction discovery using high-throughput experimentation (HTE) methods and its application towards enabling novel library syntheses and utility in addressing challenges in hypothesis driven medicinal chemistry.

Dr. Stauffer served as co-director within the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, (MLPCN, 2008-2014) and oversaw the development of over a dozen probe molecules, many leading to in vivo POM studies. In addition, during this time Dr. Stauffer co-led a J&J (Janssen) sponsored drug discovery team within the Center for Neuroscience Drug Discovery focusing on novel small molecule positive allosteric modulators of the metabotropic glutamate receptor 5 for the treatment of schizophrenia, leading to NME candidate selection and a subsequent backup program (2009-2012).

Dr. Stauffer currently serves as associate director of medicinal chemistry within the VICB SynCore where he directs several collaborative medchem projects and is a member of the Fesik Drug Discovery Group where he oversees a protein-protein interaction inhibitor project utilizing fragment-based screening methods and an integrated structure-based-design approach.

Selected Publications