David Weaver, Ph.D.

Associate Professor of Pharmacology

459 Robinson Research Building, Nashville, TN, 37232-6600
(615) 936-6461 (office)

Research Description

My research is focused on the discovery and characterization of novel chemical tools for studying ion channel structure, function, and therapeutic potential.

Specifically, the projects in my lab are focused on two key roles of ion channels in medicine and public health. The first project area deals with development of drug-like chemical tools for evaluating the role of ligand and voltage-activated potassium channels for the treatment of pain, one the largest unmet medical needs. Recent discoveries in the laboratory are paving the way for the field's first opportunites to evaluate a novel ion channel pain target.

The techniques most most commonly used in the laboratory are plate-based fluorescent assays of ion channel function, automated high-throughput screening, and whole-cell electrophysiology. My laboratory collaborates closely with medicinal chemists, imformaticians, structural biologists, engineers, and software developers.

Selected Publications