Neuropharmacology

Paul Newhouse, M.D.

Professor of Psychiatry and Behavioral Sciences

Jim Turner Chair in Cognitive Disorders

Department of Psychiatry Vanderbilt University School of Medicine 1601 23rd Ave. South, Nashville, TN, 37212

Research Description

The cognitive basis for neuropsychiatric disorders, the effects of brain cholinergic systems and sex hormones on human cognitive functioning, and experimental medicine including the development of novel treatments for Alzheimer’s disease and other disorders of cognitive aging.

Clinical Interest

Dr. Newhouse joined the faculty in 2011 and holds the Jim Turner Chair of Cognitive Disorders at Vanderbilt University School of Medicine and is Professor of Psychiatry, Pharmacology, and Medicine. He is Director of the Center for Cognitive Medicine and the Division of Geriatric Psychiatry in the Department of Psychiatry and Behavioral Sciences at Vanderbilt University Medical Center. He is also Training Director for the Vanderbilt TVHS Geriatric Psychiatry Fellowship. He is also a physician-­-scientist at the VA Tennessee Valley Health Systems Geriatric Research, Education, and Clinical Center (GRECC).

Dr. Newhouse's research has focused on central nicotinic mechanisms in aging and the role of nicotinic receptor systems in normal and disordered cognitive functioning in humans. He has also emphasized the development of novel cholinergic agents for clinical use in cognitive disorders. A second major focus includes studying the interaction of estrogen and related molecules on central cholinergic systems in relation to cognitive and emotional aging through the use of novel pharmacologic-­-imaging methodologies.