Primary Faculty/Secondary Faculty

Richard Gumina, Ph.D., M.D.

Assistant Professor of Medicine

2220 Pierece Ave South, Nashville, TN, 37232

Research Description

Dr. Gumina is a Physician-Scientist (PhD-MD) Interventional Cardiologist with an active research program examining the role of extracellular nucleotide regulation in cardiovascular disease. The laboratory is focused on understanding the molecular mechanisms that influence the levels of extracellular ATP and ADP following vascular or myocardial injury. The lab uses both animal models and human tissue, cell and genetic sampling to address the role of nucleotidases in cardiovascular disease. The overall goal of this work is to understand how innate regulation of extracellular nucleotide/nucleoside metabolism modifies myocardial injury and healing in human pathophysiology. With the insights gained through these investigations we will develop novel approaches, diagnostics and therapies to improve the treatment of patients with acute coronary syndromes and coronary artery disease.

Clinical Interest

Our lab is interested in understanding how differences in the expression and activity of key ectonucleotidases modulate human immune cell function, the development of atherosclerosis and impact the risks for cardiovascular disease.

Selected Publications