The signaling group within the Department of Pharmacology at Vanderbilt University is comprised of a broad, multi-disciplinary team of investigators who study the intricate transduction networks that govern the ability of cells to respond to stimuli in their microenvironment. Our researchers exploit state-of-the-art technologies and diverse model systems (e.g., Drosophila, C. elegans, zebrafish, and mice) to address fundamentally important questions in the signaling field that are relevant to human disease. The ultimate goal of our investigators is to translate their basic science discoveries into new therapeutics for various human diseases.