Matthew Wleklinski
The Knollmann Lab is interested in studying various arrhythmias, their development, and how to treat them. One of the main arrhythmias they focus on is catecholaminergic polymorphic ventricular tachycardia (CPVT). My current research interest is to study CPVT and try to understand the calcium handling that causes these to form. We are looking at using various mouse models that have knock out mutations in calsequestrin from different patient populations to understand how these mutations affect calsequestrin and lead to the generation of these arrhythmias.