Trauma-induced skeletal muscle calcification is a spectrum of disease, including dystrophic calcification and heterotopic ossification (HO), that may occur following severe injuries such as burn, blast, neurologic and musculoskeletal injuries, as well as certain orthopaedic procedures. Under normal physiologic circumstances, when the body undergoes injury, innate protection mechanisms inhibit the formation of calcification within skeletal muscle. Additionally, the body also possesses mechanisms to remove mineral deposits formed in damaged tissues, thereby allowing for proper tissue healing and regeneration. The goal of my project is to identify critical skeletal muscle protection mechanisms and the mechanisms by which calcification is regressed from damaged tissues. Through identifying the mechanism at work, I am now examining novel therapeutics aimed at enhancing these mechanism to better prevent soft tissue calcification.
Graduate Student, Schoenecker laboratory
BS, Ohio Northern University (2003)