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Reecan Juarez

CUNY Hunter College

Zhongyue (John) Yang lab

Lasso peptides are cyclic peptides that maintain a unique fold with two amino acid “plugs.” My project focuses on elucidating the structural and chemical features that allow these plugs to maintain this fold. This will be done through molecular dynamics simulations, allowing the calculation of thermodynamic parameters such as free energy associated with amino acid plug passage through the cyclic peptide.