{"id":13,"date":"2018-08-20T20:18:35","date_gmt":"2018-08-20T20:18:35","guid":{"rendered":"https:\/\/medschool.prd.vanderbilt.edu\/qcb\/program-overview\/"},"modified":"2025-07-08T18:47:17","modified_gmt":"2025-07-08T18:47:17","slug":"program-overview","status":"publish","type":"page","link":"https:\/\/medschool.vanderbilt.edu\/qcb\/program-overview\/","title":{"rendered":"Program Overview"},"content":{"rendered":"<p>Quantitative and Chemical Biology is a transinstitutional first-year graduate program designed for students who wish to pursue a doctoral degree with a research focus at the interfaces between physical, chemical, and biological sciences. Students entering QCB typically have earned undergraduate degrees in chemistry, physics, computer science, engineering, or mathematics.<\/p>\n<p>Previous coursework in biology and biomedical science is not required for entry into the QCB program. Students with a strong background in biology should consider our sister program, the <a href=\"https:\/\/medschool.vanderbilt.edu\/igp\/\">Interdisciplinary Graduate Program in the Biological and Biomedical Sciences (IGP)<\/a>. A unique aspect of the QCB Program is that students have the flexibility to explore their research interests from the offerings of the thirteen participating departments and programs prior to choosing a laboratory for their dissertation research.<\/p>\n<p>More specifics on the first year QCB curriculum can be found <a href=\"https:\/\/medschool.vanderbilt.edu\/qcb\/prospective-students\/training-program\/\">here<\/a>.<\/p>\n<p>While students in the first year QCB curriculum can pursue any interests in the biomedical sciences, the coursework generally follows one of four areas of interest:<\/p>\n<ul>\n<li><a href=\"#block-bean-chemical-biology\">Chemical Biology<\/a><\/li>\n<li><a href=\"#block-bean-structural-biology-molecular-bi\">Structural Biology &amp; Molecular Biophysics<\/a><\/li>\n<li><a href=\"#block-bean-systems-biology\">Systems Biology<\/a><\/li>\n<li><a href=\"#block-bean-imaging-sciences\">Imaging Science<\/a><\/li>\n<\/ul>\n<div class='row'>\n<div class='col-lg-6'>\n<h2 id=\"block-bean-chemical-biology\">Chemical Biology<\/h2>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/48\/files\/resize\/public_files\/CPBP16-450x180.jpg\" alt=\"CPBP16.jpg\" width=\"100%\" \/><\/p>\n<p><strong>Research Focus:<\/strong><\/p>\n<p>The chemical biology curriculum provides advanced training and research at the chemistry biology interface using chemical approaches to understand biological systems. Research opportunities are available in abroad range of areas including:<\/p>\n<p class=\"rteindent1\">Biological Mass Spectroscopy<br \/>\nBiomagnetics and Nonlinear Dynamics<br \/>\nComputational Biology and Molecular Modeling<br \/>\nProtein-protein Interactions<br \/>\nNMR and EPR<br \/>\nDrug Discovery<br \/>\nChemical Biology<br \/>\nProtein-Nucleic Acid Interactions<br \/>\nFluorescence Spectroscopy and Microscopy Structural Biology<br \/>\nNanocrystals<br \/>\nMacromolecular Structure and Dynamics<br \/>\nMechanistic Enzymology<br \/>\nProteomics<br \/>\nMolecular Toxicology<br \/>\nMathematical Modeling of Biological Systems<br \/>\nStructural Biology<\/p>\n<p><strong>Examples of Coursework<\/strong><\/p>\n<p class=\"rteindent1\">Biological Mass Spectroscopy<br \/>\nBiomagnetics and Nonlinear Dynamics<br \/>\nComputational Biology and Molecular Modeling<br \/>\nProtein-protein Interactions<br \/>\nNMR and EPR<br \/>\nDrug Discovery<br \/>\nChemical Biology<br \/>\nProtein-Nucleic Acid Interactions<br \/>\nFluorescence Spectroscopy and Microscopy Structural Biology<br \/>\nNanocrystals<br \/>\nMacromolecular Structure and Dynamics<br \/>\nMechanistic Enzymology<br \/>\nProteomics<br \/>\nMolecular Toxicology<br \/>\nMathematical Modeling of Biological Systems<br \/>\nStructural Biology<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class='col-lg-6'>\n<h2 id=\"block-bean-structural-biology-molecular-bi\">Structural Biology &amp; Molecular Biology<\/h2>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/48\/files\/resize\/public_files\/20080806JR010-450x180.JPG\" alt=\"20080806JR010.JPG\" width=\"100%\" \/><\/p>\n<p><strong>Research Focus:<\/strong><br \/>\nThe curriculum prepares students for research careers in structural biology, molecular biophysics, or computational biology. Research opportunities are available in a broad range of areas including:<\/p>\n<p class=\"rteindent1\">Alzheimer&#8217;s disease and protein folding disorders<br \/>\nGenome maintenance and cancer<br \/>\nMechanistic enzymology<br \/>\nMembrane protein structure and function<br \/>\nMolecular toxicology<br \/>\nViral and bacterial pathogenesis<br \/>\nComputational biology and structure-based design<br \/>\nCryo-electron microscopy<br \/>\nEPR Spectroscopy<br \/>\nFluorescence<br \/>\nNMR spectroscopy and solution scattering<br \/>\nSuper-resolution microscopy<br \/>\nX-ray crystallography<\/p>\n<p><strong>Example of Coursework:<\/strong><\/p>\n<p class=\"rteindent1\">Advanced Membrane Protein Biology: From Molecule to Disease<br \/>\nBasic Biological Microscopy<br \/>\nBiochemistry: Basis of Biological Processes<br \/>\nBiomolecular NMR Spectroscopy<br \/>\nBiomolecular Physics<br \/>\nBiomolecular X-Ray Crystallography<br \/>\nComputational Structural Biochemistry<br \/>\nDNA Structure and Topology<br \/>\nDrug Design and Development<br \/>\nGraduate Seminar in Molecular Biophysics<br \/>\nIntroduction to Structural Biology<br \/>\nIntroduction to Modern Biological Microscopy<br \/>\nMedical Chemistry<br \/>\nMolecular Modeling Methods<br \/>\nMolecular Structure and Function<br \/>\nProtein-Protein Interactions Make Cells Go Round<br \/>\nQuantum Chemistry<br \/>\nReceptor Theory and Enzyme Kinetics<br \/>\nSpectroscopy<\/p>\n<\/div>\n<\/div>\n<div class='row'>\n<div class='col-lg-6'>\n<h2 id=\"block-bean-systems-biology\">Systems Biology<\/h2>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/48\/files\/resize\/public_files\/CPBP06-450x180.jpg\" alt=\"CPBP06.jpg\" width=\"100%\" \/><\/p>\n<p><strong>Research Focus<\/strong><\/p>\n<p>Systems Biology students receive training not only in a specific biological research field, but also in the acquisition and integration of different types of quantitative data from different platforms (genomics, gene expression, proteomics, molecular, cellular, and functional data). Since these multiscale data are extremely complex, quantitative mathematical and computational modeling is required for analysis and prediction. This approach is distinct from traditional biomedical research, although it has many aspects in common with approaches that form the core of the program (biophysics, structural biology, chemical biology, and imaging science). Students in Systems Biology will take a flexible curriculum that permits in-depth coursework in both a specific disease model and state-of-the-art quantitative approaches, including mathematical modeling.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Examples of Coursework:<\/strong><\/p>\n<p class=\"rteindent1\">Molecular Structure and Function<br \/>\nQuantum Chemistry<br \/>\nMedicinal Chemistry<br \/>\nPhysics of Medical Imaging<br \/>\nMolecular Modeling Methods<br \/>\nComputational Structural Biochemistry<br \/>\nBiological Basis of Imaging<br \/>\nQuantitative and Functional Imaging<br \/>\nMathematical Methods in Imaging sciences<br \/>\nFoundations in Bioinformatics Neuroimaging<br \/>\nSystems Biology<br \/>\nCancer Systems Biology<br \/>\nPhysical Measurements of Biological Systems<br \/>\nTheoretical and Experimental Systems Biology<br \/>\nBiophysical Models of Cancer<br \/>\nMolecular Endocrinology<br \/>\nAdvanced Concepts in Cancer Biology<br \/>\nCell Biology<br \/>\nCellular and Molecular Neuroscience<br \/>\nMolecular and Cellular Immunology<\/p>\n<\/div>\n<div class='col-lg-6'>\n<h2 id=\"block-bean-imaging-sciences\">Imaging Sciences<\/h2>\n<p><img decoding=\"async\" src=\"\/wp-content\/uploads\/sites\/48\/files\/resize\/public_files\/CPBP27-450x180.jpg\" alt=\"CPBP27.jpg\" width=\"100%\" \/><\/p>\n<p><strong>Research Focus:<\/strong><\/p>\n<p>The imaging science curriculum provides advanced training in the physical, chemical, engineering, mathematical, medical, and biological aspects of modern in vivo imaging and spectroscopy. Students have access to an extensive didactic curriculum that includes core courses on the fundamental aspects of imaging science, courses in specialized areas of imaging sciences, and the biomedical sciences. Students may also select from a wide variety of research project opportunities, ranging from the fundamental physical aspects of image formation and contrast generation through to applications of imaging methods in clinical populations.\u00a0<strong>Example research areas include:<\/strong><\/p>\n<p class=\"rteindent1\">Imaging Systems Hardware<br \/>\nMRI Pulse Sequence Development<br \/>\nImage Reconstruction<br \/>\nFunctional and Structural Neuroimaging<br \/>\nIn Vivo Spectroscopy<br \/>\nImaging and Spectroscopy with Hyperpolarized Species<br \/>\nPhysiological and Metabolic Imaging<br \/>\nImage-based Modeling<br \/>\nMusculoskeletal Imaging<br \/>\nComputational Imaging<br \/>\nUltrasound: Imaging and Therapy<br \/>\nContrast Mechanisms in MRI<br \/>\nNuclear Imaging Methods and Applications<br \/>\nStatistical Image Analysis<br \/>\nCellular and Molecular Imaging<br \/>\nCancer Imaging<br \/>\nOptical Imaging<br \/>\nImaging Biomarkers<\/p>\n<p><strong>Examples of Coursework<\/strong><\/p>\n<p class=\"rteindent1\">Foundations of Medical Imaging<br \/>\nPhysics of Medical Imaging<br \/>\nBiological Basis of Imaging<br \/>\nQuantitative and Functional Imaging<br \/>\nCellular and Molecular Imaging<br \/>\nCurrent Topics in Imaging Science<br \/>\nImage Processing<br \/>\nAdvanced Image Processing<br \/>\nNeuroimaging<br \/>\nMathematical Methods in Imaging Science<br \/>\nCancer Imaging<br \/>\nMathematical Methods for Physicists<br \/>\nQuantitative Methods in Biomedical Engineering<br \/>\nMolecular Probe Development<br \/>\nMagnetic Resonance Imaging<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Quantitative and Chemical Biology is a transinstitutional first-year graduate program designed for students who wish to pursue a doctoral degree with a research focus at the interfaces between physical, chemical, and biological sciences. Students entering QCB typically have earned undergraduate degrees in chemistry, physics, computer science, engineering, or mathematics. Previous coursework in biology and biomedical&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-13","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/pages\/13","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":15,"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/pages\/13\/revisions"}],"predecessor-version":[{"id":1204,"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/pages\/13\/revisions\/1204"}],"wp:attachment":[{"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/media?parent=13"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/qcb\/wp-json\/wp\/v2\/tags?post=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}