Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells.
AUTHORS
Petersen
CP ,
Weis
VG ,
Nam
KT ,
Sousa
JF ,
Fingleton
B ,
Goldenring
JR ,
. Gastroenterology. 2014 6 ; 146(7). 1727-38.e8
- PMID: 24534633 [PubMed].
- PMCID: PMC4035414.
- NIHMSID: NIHMS568373
ABSTRACT
Loss of parietal cells causes the development of spasmolytic polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief cells. In the presence of inflammation, SPEM can advance into a more proliferative metaplasia with increased expression of intestine-specific transcripts. We used L635 to induce acute SPEM with inflammation in mice and investigated the roles of inflammatory cells in the development of SPEM.
Tags: enabled-2014