Potent STING Activation Stimulates Immunogenic Cell Death to Enhance Antitumor Immunity in Neuroblastoma;
AUTHORS
Wang-Bishop
Lihong ,
Wahbe
Mohamed ,
Shae
Daniel ,
James
Jamaal ,
Hacker
Benjamin ,
Garland
Kyle ,
Christov
Plamen ,
Rafat
Marjan ,
Balko
Justin ,
Wilson
John ,
. J Immunother Cancer. 2020 3 ; 8(1). 1-17
- PMID: 32169869 [PubMed].
- PMCID: PMC7069313.
ABSTRACT
Neuroblastoma (NB) is a childhood cancer for which new treatment options are needed. The success of immune checkpoint blockade in the treatment of adult solid tumors has prompted the exploration of immunotherapy in NB; however, clinical evidence indicates that the vast majority of NB patients do not respond to single-agent checkpoint inhibitors. This motivates a need for therapeutic strategies to increase NB tumor immunogenicity. The goal of this study was to evaluate a new immunotherapeutic strategy for NB based on potent activation of the stimulator of interferon genes (STING) pathway.
Tags: 2020