Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function;
AUTHORS
Davis
Robert ,
Allweil
Alexander ,
Tian
Jianhua ,
Brash
Alan ,
Sulikowski
Gary ,
. Tetrahedron Letter. 2018 12 26; 59(52). 4571-4573
- PMID: 30906077 [PubMed].
- PMCID: PMC6424341.
ABSTRACT
Linoleate triol esters are intermediates along the pathway of formation of the mammalian skin permeability barrier. In connection with the study of their involvement in barrier formation we required access to isomerically pure and defined samples of four linoleate triol esters. A common synthetic strategy was developed starting from isomeric alkynols derived from d-tartaric acid and 2-deoxy-d-ribose.
Tags: 2018