• Romaine IM, Sulikowski GA. Studies on a biomimetic oxidative dimerization approach to the hibarimicins. Tetrahedron letters. 2015 Jun 3;56(23). 3617-3619. PMID: 26236055 [PubMed]. PMCID: PMC4518470. NIHMSID: NIHMS658459.


Nature utilizes dimerization as a method of producing structurally complex metabolites. The microbial metabolites known collectively as the hibarimicins are one example of complex natural products produced biosynthetically by dimerization of a phenolic aromatic polyketide. Described in this communication are model studies aimed at demonstrating regiocontrolled oxidative dimerization of phenolic ring systems related to the biosynthetic precursor of the hibarimicin family of natural products.