• Shifrin DA, Tyska MJ. Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense. Gut microbes. 3(5). 460-2. PMID: 22825496 [PubMed]. PMCID: PMC3466500.


Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.