{"id":366,"date":"2015-02-10T20:17:39","date_gmt":"2015-02-10T20:17:39","guid":{"rendered":"http:\/\/www.mc.vanderbilt.edu\/vanderbiltmedicine\/?p=366"},"modified":"2021-08-11T19:41:42","modified_gmt":"2021-08-11T19:41:42","slug":"high-dose-flu-vaccine-more-effective-in-elderly-vanderbilt-led-study-shows","status":"publish","type":"post","link":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/high-dose-flu-vaccine-more-effective-in-elderly-vanderbilt-led-study-shows\/","title":{"rendered":"High-dose flu vaccine more effective in elderly, Vanderbilt-led study shows"},"content":{"rendered":"<figure id=\"attachment_533\" aria-describedby=\"caption-attachment-533\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/www.mc.vanderbilt.edu\/vanderbiltmedicine\/wp-content\/uploads\/sites\/7\/2015\/02\/Flu-file-SU0151.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-533\" src=\"http:\/\/www.mc.vanderbilt.edu\/vanderbiltmedicine\/wp-content\/uploads\/sites\/7\/2015\/02\/Flu-file-SU0151-300x231.jpg\" alt=\"Photo by Susan Urmy\" width=\"300\" height=\"231\" srcset=\"https:\/\/cdn.vanderbilt.edu\/t2-main\/medschool-prd\/wp-content\/uploads\/sites\/82\/2015\/02\/Flu-file-SU0151-300x231.jpg 300w, https:\/\/cdn.vanderbilt.edu\/t2-main\/medschool-prd\/wp-content\/uploads\/sites\/82\/2015\/02\/Flu-file-SU0151.jpg 576w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-533\" class=\"wp-caption-text\">Photo by Susan Urmy<\/figcaption><\/figure>\n<p>High-dose influenza vaccine is 24 percent more effective than the standard-dose vaccine in protecting persons ages 65 and over against influenza illness\u00a0and its complications, according to a\u00a0Vanderbilt-led study published in August 2014 in the New England Journal of Medicine (NEJM).<\/p>\n<p>The multi-center study enrolled 31,989 participants from 126 research centers in the U.S. and Canada during the 2011-2012 and 2012-2013 influenza seasons in the Northern Hemisphere in order to compare the high-dose trivalent vaccine versus the standard-dose trivalent vaccine in adults over 65.<\/p>\n<p>Researchers concluded that the high-dose vaccine is safe, induces significantly higher antibody responses, and provides superior protection against laboratory-confirmed influenza illness compared to standard dose among persons over 65.<\/p>\n<p>Study data also indicated that the high-dose vaccine may provide clinical benefit for the prevention of hospitalizations, pneumonia, cardio-respiratory conditions, non-routine medical visits, and medication use.<\/p>\n<p>Adults over 65 are particularly vulnerable to influenza complications, accounting for most seasonal influenza-related hospitalizations and deaths. n Craig Boerner<\/p>\n","protected":false},"excerpt":{"rendered":"<p>High-dose influenza vaccine is 24 percent more effective than the standard-dose vaccine in protecting persons ages 65 and over against influenza illness\u00a0and its complications, according to a\u00a0Vanderbilt-led study published in August 2014 in the New England Journal of Medicine (NEJM). The multi-center study enrolled 31,989 participants from 126 research centers in the U.S. and Canada&#8230;<\/p>\n","protected":false},"author":211,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_links_to":"","_links_to_target":""},"categories":[11,29],"tags":[],"class_list":["post-366","post","type-post","status-publish","format-standard","hentry","category-vm-around-the-medical-center","category-vm-winter-2015"],"acf":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pcDnub-5U","_links":{"self":[{"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/posts\/366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/users\/211"}],"replies":[{"embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/comments?post=366"}],"version-history":[{"count":1,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/posts\/366\/revisions"}],"predecessor-version":[{"id":3170,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/posts\/366\/revisions\/3170"}],"wp:attachment":[{"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/media?parent=366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/categories?post=366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medschool.vanderbilt.edu\/vanderbilt-medicine\/wp-json\/wp\/v2\/tags?post=366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}