- Savage SW, Zald DH, Cowan RL, Volkow ND, Marks-Shulman PA, Kessler RM, Abumrad NN, Dunn JP. Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity. Obesity (Silver Spring, Md.). 2014 Jun;22(6). 1452-7. PMID: 24415718 [PubMed]. PMCID: PMC4037348. NIHMSID: NIHMS554595.
To investigate the relationship of novelty seeking traits (NS) with midbrain dopamine (DA) receptors and acyl ghrelin levels (AG) in normal weight (NW) and obese females.NS predict addictive behaviors and are hypothesized to contribute to eating behaviors. In healthy, NS are negatively associated with DA receptors in the substantia nigra (SN). The influence of obesity on the regulation of NS by DA signaling and AG was hypothesized.