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Research Areas

Research by VCAR investigators spans a broad spectrum ranging from developing an understanding of the molecular understanding of actions of drugs of abuse and alcohol to development of novel pharmaceutical interventions to gaining an understanding of individual variation in human brain activity. Recent examples are listed below.

Development and Refinement of Pharmaceutical Strategies to Treat Addiction

GouldRW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK, Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychot…Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMC4748441 Mar 41 (4). 1166-78
BruehlS, Burns JW, Passik SD, Gupta R, Buvanendran A, Chont M, Schuster E, Orlowska D, France CR, The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic P…The journal of pain : official journal of the American Pain Society. PMC4486517 Jul 16 (7). 666-75
NickolsHH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ, VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor wi…The Journal of pharmacology and experimental therapeutics. PMC4702078 Jan 356 (1). 123-36

Fundamental Neuroscience of Addiction Brain Circuits

WallaceMT, Multisensory Perception: The Building of Flavor Representations.Current biology : CB. Oct 19 25 (20). R986-8
GuH, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q, A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses.Stem cells translational medicine. PMC4511147 Aug 4 (8). 887-93
FosterDJ, Gentry PR, Lizardi-Ortiz JE, Bridges TM, Wood MR, Niswender CM, Sulzer D, Lindsley CW, Xiang Z, Conn PJ, M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the…The Journal of neuroscience : the official journal of the Society for Neuroscience. PMC3935086 Feb 26 34 (9). 3253-62
DeutchAY, Extending Corticostriatal Systems.JAMA psychiatry. Aug 1 73 (8). 871-2
MingoteS, Chuhma N, Kusnoor SV, Field B, Deutch AY, Rayport S, Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience. PMC4682788 Dec 9 35 (49). 16259-71
DayJJ, Kennedy AJ, Sweatt JD, DNA methylation and its implications and accessibility for neuropsychiatric therapeutics.Annual review of pharmacology and toxicology. PMC4768530 55 591-611
DayJJ, Childs D, Guzman-Karlsson MC, Kibe M, Moulden J, Song E, Tahir A, Sweatt JD, DNA methylation regulates associative reward learning.Nature neuroscience. PMC3785567 Oct 16 (10). 1445-52

Preclinical Models of Addiction and Negative Affect

DayJJ, Kennedy AJ, Sweatt JD, DNA methylation and its implications and accessibility for neuropsychiatric therapeutics.Annual review of pharmacology and toxicology. PMC4768530 55 591-611
DayJJ, Childs D, Guzman-Karlsson MC, Kibe M, Moulden J, Song E, Tahir A, Sweatt JD, DNA methylation regulates associative reward learning.Nature neuroscience. PMC3785567 Oct 16 (10). 1445-52
HolleranKM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG, Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During For…Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMC4908652 Jul 41 (8). 2062-71
WillsTA, Baucum AJ, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG, Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates grou…Addiction biology. PMC4860359 Nov 8
ShonesyBC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S, Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signal…Cell reports. PMC4268380 Dec 11 9 (5). 1644-53
ReddyIA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A, Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in th…Translational psychiatry. 6 e809
DadalkoOI, Siuta M, Poe A, Erreger K, Matthies HJ, Niswender K, Galli A, mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neuro…The Journal of neuroscience : the official journal of the Society for Neuroscience. PMC4461689 Jun 10 35 (23). 8843-54
MorenaM, Patel S, Bains JS, Hill MN, Neurobiological Interactions Between Stress and the Endocannabinoid System.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMC4677118 Jan 41 (1). 80-102
RamikieTS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S, Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamat…Neuron. PMC3955008 Mar 5 81 (5). 1111-25

Public Policy, Society and Addiction/Alcoholism

HylandA, Piazza K, Hovey KM, Tindle HA, Manson JE, Messina C, Rivard C, Smith D, Wactawski-Wende J, Associations between lifetime tobacco exposure with infertility and age at natural menopause: the Wo…Tobacco control. Dec 14
DonnyEC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK, Randomized Trial of Reduced-Nicotine Standards for Cigarettes.The New England journal of medicine. PMC4642683 Oct 373 (14). 1340-9
PatrickSW, Fry CE, Jones TF, Buntin MB, Implementation Of Prescription Drug Monitoring Programs Associated With Reductions In Opioid-Related…Health affairs (Project Hope). Jul 1 35 (7). 1324-32
KransEE, Patrick SW, Opioid Use Disorder in Pregnancy: Health Policy and Practice in the Midst of an Epidemic.Obstetrics and gynecology. PMC4917415 Jul 128 (1). 4-10
PatrickSW, Schumacher RE, Horbar JD, Buus-Frank ME, Edwards EM, Morrow KA, Ferrelli KR, Picarillo AP, Gupta M, Soll RF, Improving Care for Neonatal Abstinence Syndrome.Pediatrics. PMC4845877 May 137 (5).
PatrickSW, Davis MM, Lehmann CU, Lehman CU, Cooper WO, Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009…Journal of perinatology : official journal of the California Perinatal Association. PMC4520760 Aug 35 (8). 650-5
ToliaVN, Patrick SW, Bennett MM, Murthy K, Sousa J, Smith PB, Clark RH, Spitzer AR, Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs.The New England journal of medicine. May 28 372 (22). 2118-26
PatrickSW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO, Prescription opioid epidemic and infant outcomes.Pediatrics. PMC4411781 May 135 (5). 842-50
TindleHA, Daigh R, Reddy VK, Bailey LA, Ochs JA, Maness MH, Davis EM, Schulze AE, Powers KM, Ylioja TE, Baca HB, Mast JL, Freiberg MS, , eReferral Between Hospitals and Quitlines: An Emerging Tobacco Control Strategy.American journal of preventive medicine. Jul 28
VidrineJI, Spears CA, Heppner WL, Reitzel LR, Marcus MT, Cinciripini PM, Waters AJ, Li Y, Nguyen NT, Cao Y, Tindle HA, Fine M, Safranek LV, Wetter DW, Efficacy of Mindfulness-Based Addiction Treatment (MBAT) for Smoking Cessation and Lapse Recovery: A…Journal of consulting and clinical psychology. May 23
CarpenterCS, Dobkin C, Warman C, The Mechanisms of Alcohol Control.The Journal of human resources. PMC4843837 51 (2). 328-356
CarpenterC, Dobkin C, The Minimum Legal Drinking Age and Crime.The review of economics and statistics. PMC4477871 May 97 (2). 521-524
BrucknerTA, Domina T, Hwang JK, Gerlinger J, Carpenter C, Wakefield S, State-level education standards for substance use prevention programs in schools: a systematic conte…The Journal of adolescent health : official publication of the Society for Adolescent Medicine. PMC3947729 Apr 54 (4). 467-73
Christie-MizellC. Andre, Pirtle Whitney, Tyndall Benjamin, Merolla David, Race–gender differences in the impact of history of heavy drinking on current alcohol consumption …Journal of Sociology and Social Welfare. Sep 1 42 (3). 137-58

    Treatment Strategies

    HylandA, Piazza K, Hovey KM, Tindle HA, Manson JE, Messina C, Rivard C, Smith D, Wactawski-Wende J, Associations between lifetime tobacco exposure with infertility and age at natural menopause: the Wo…Tobacco control. Dec 14
    DonnyEC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK, Randomized Trial of Reduced-Nicotine Standards for Cigarettes.The New England journal of medicine. PMC4642683 Oct 373 (14). 1340-9
    MartinPR, Finlayson AJ, Opioid use disorder during pregnancy in Tennessee: expediency vs. science.The American journal of drug and alcohol abuse. 41 (5). 367-70
    FerriM, Finlayson AJ, Wang L, Martin PR, Predictive factors for relapse in patients on buprenorphine maintenance.The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions. PMC3922612 23 (1). 62-7
    FinlaysonAJ, Dietrich MS, Neufeld R, Roback H, Martin PR, Restoring professionalism: the physician fitness-for-duty evaluation.General hospital psychiatry. PMC3923266 35 (6). 659-63
    PatrickSW, Fry CE, Jones TF, Buntin MB, Implementation Of Prescription Drug Monitoring Programs Associated With Reductions In Opioid-Related…Health affairs (Project Hope). Jul 1 35 (7). 1324-32
    KransEE, Patrick SW, Opioid Use Disorder in Pregnancy: Health Policy and Practice in the Midst of an Epidemic.Obstetrics and gynecology. PMC4917415 Jul 128 (1). 4-10
    PatrickSW, Schumacher RE, Horbar JD, Buus-Frank ME, Edwards EM, Morrow KA, Ferrelli KR, Picarillo AP, Gupta M, Soll RF, Improving Care for Neonatal Abstinence Syndrome.Pediatrics. PMC4845877 May 137 (5).
    PatrickSW, Davis MM, Lehmann CU, Lehman CU, Cooper WO, Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009…Journal of perinatology : official journal of the California Perinatal Association. PMC4520760 Aug 35 (8). 650-5
    ToliaVN, Patrick SW, Bennett MM, Murthy K, Sousa J, Smith PB, Clark RH, Spitzer AR, Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs.The New England journal of medicine. May 28 372 (22). 2118-26
    PatrickSW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO, Prescription opioid epidemic and infant outcomes.Pediatrics. PMC4411781 May 135 (5). 842-50
    TindleHA, Daigh R, Reddy VK, Bailey LA, Ochs JA, Maness MH, Davis EM, Schulze AE, Powers KM, Ylioja TE, Baca HB, Mast JL, Freiberg MS, , eReferral Between Hospitals and Quitlines: An Emerging Tobacco Control Strategy.American journal of preventive medicine. Jul 28
    VidrineJI, Spears CA, Heppner WL, Reitzel LR, Marcus MT, Cinciripini PM, Waters AJ, Li Y, Nguyen NT, Cao Y, Tindle HA, Fine M, Safranek LV, Wetter DW, Efficacy of Mindfulness-Based Addiction Treatment (MBAT) for Smoking Cessation and Lapse Recovery: A…Journal of consulting and clinical psychology. May 23

    Human Brain Imaging Insights Into Addiction and Mental Health

    DangLC, Samanez-Larkin GR, Castrellon JJ, Perkins SF, Cowan RL, Zald DH, Associations between dopamine D2 receptor availability and BMI depend on age.NeuroImage. PMC4927378 Sep 138 176-83
    TreadwayMT, Zald DH, Parsing Anhedonia: Translational Models of Reward-Processing Deficits in Psychopathology.Current directions in psychological science. PMC3989147 Jun 1 22 (3). 244-249
    SavageSW, Zald DH, Cowan RL, Volkow ND, Marks-Shulman PA, Kessler RM, Abumrad NN, Dunn JP, Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity…Obesity (Silver Spring, Md.). PMC4037348 Jun 22 (6). 1452-7
    AverySN, Clauss JA, Blackford JU, The Human BNST: Functional Role in Anxiety and Addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMC4677124 Jan 41 (1). 126-41
    ClaussJA, Avery SN, VanDerKlok RM, Rogers BP, Cowan RL, Benningfield MM, Blackford JU, Neurocircuitry underlying risk and resilience to social anxiety disorder.Depression and anxiety. PMC4314099 Oct 31 (10). 822-33
    AverySN, Clauss JA, Winder DG, Woodward N, Heckers S, Blackford JU, BNST neurocircuitry in humans.NeuroImage. PMC4214684 May 1 91 311-23