The Vanderbilt Center for Bone Biology (VCBB) was created to investigate diseases of bone and mineral metabolism. Investigators associated with VCBB study the mechanisms regulating embryonic bone development, adult bone remodeling and repair, as well as cancers such as breast cancer and prostate cancer, which frequently affect the skeleton. Our goals are to unravel novel biological mechanisms and to develop new treatments and diagnostic tools that can eventually change the quality of life for patients with bone diseases. Access to multiple state-of-the-art instruments and cores at VUMC allows us to perform molecular, cellular and biochemical studies, and to precisely quantify changes in bone volume, architecture, biomechanical properties and histology upon gene alterations, growth, aging, disease or pharmacologic treatments. Students from multiple departments, including Medicine, Cancer Biology, Pharmacology and Engineering are actively involved in this research activity. The active VCBB research program is detailed in the tabs above. Feel free to contact the project leaders or associated students/post-docs if you have questions about projects and if you have interests in joining our group.
Leslie J. Crofford, Director
For VCBB members:
You can access the “collaboration” website via this page to find primers, plasmids, antibodies and protocols used in the different VCBB labs.
Want to improve your manuscript reviewing and writing skills? Join the Review Journal Club. Students, post-docs and faculty can join by contacting Dr. Crofford.