{"id":315,"date":"2023-03-30T21:01:29","date_gmt":"2023-03-30T21:01:29","guid":{"rendered":"https:\/\/medschool.prd.vanderbilt.edu\/newvger\/?page_id=315"},"modified":"2026-05-26T15:32:02","modified_gmt":"2026-05-26T15:32:02","slug":"vanderbilt-genome-editing-resource","status":"publish","type":"page","link":"https:\/\/medschool.vanderbilt.edu\/vger\/","title":{"rendered":"Vanderbilt Genome Editing Resource"},"content":{"rendered":"\n\n      <!-- 3up Factoid -->\n      <section data-component=\"Factoids\" id=\"\">\n              <h2 data-jumplink=\"true\" data-jumptitle=\"Impact\">IMPACT<\/h2>\n        <ul>\n                  <li>\n            <strong>&gt;230<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/mouse-services-copy-2\/\">CRISPR-edited alleles<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>20<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/mouse-services-copy-2\/\">sgRNA expression models (CRISPRi)<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>4<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/genome-modified-human-ipscs\/\">CRISPR-edited hPSCs<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>4<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/mouse-services-copy-2\/\">sgRNA array models (iMAP)<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>&gt;1,100<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/cryopreservation-and-rederivation\/\">mouse lines cryopreserved<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>&gt;540<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/cryopreservation-and-rederivation-copy\/\">mouse lines rederived<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>750<\/strong>             <p>gene targeted alleles<\/p>                        \n          <\/li>\n                  <li>\n            <strong>&gt;2800<\/strong>             <p><a href=\"https:\/\/medschool.prd.vanderbilt.edu\/vger\/mouse-services\/mouse-services-copy-2\/\">transgenic founder mice<\/a><\/p>                        \n          <\/li>\n                  <li>\n            <strong>83<\/strong>             <p><a href=\"https:\/\/medschool.vanderbilt.edu\/vcmr\/\">VCMR strains<\/a><\/p>                        \n          <\/li>\n                <\/ul>\n      <\/section>\n\n.max-message {\n    display: block;\n    margin: 0 4px;\n    padding: 10px 0;\n    font-style: italic;\n}\n.factoids__description{\n  margin-bottom: 18px;\n}\n.factoids__description p,\n.factoids__description {\n  font-size: 24px;\n  font-family: &#8216;Academica&#8217;;\n  font-weight: 400;\n}\n.factoids&#8211;largelist .factoids__bg-wrapper{\n  padding-top: 36px !important;\n  margin-top: 0 !important;\n}\n@media only screen and (max-width: 767px) {\n  .factoids__description,\n  .factoids__description p{\n    font-size: 17px;\n  }\n  .factoids&#8211;largelist .factoids__bg-wrapper{\n    padding-top: 18px !important;\n  }\n}\n\n        <h2>Notable publications<\/h2>                \n          \n          \n                              <a data-card-number=\"1\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39745200\/\" target=\"_self\">\n                  <h3>Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic biliary duct formation. <\/h3>\n                                      Trinh LT, Finnel RR, Osipovich AB, Musselman JR, Sampson LL, Wright CVE, Magnuson MA. \n            <\/a>\n                      <a data-card-number=\"2\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41511443\/\" target=\"_self\">\n                  <h3>Paracrine Hormonal Signals From Islet \u03b1-Cells Regulate Microtubule Dynamics in \u03b2-Cells to Promote Insulin Secretion in Mouse and Human Islets.<\/h3>\n                                      Ho KH, Barmaver SN, Gibson SE, Hu R, Yagan M, Ahmed HK, Balamurugan AN, Jacobson DA, Kaverina I, Gu G.\n            <\/a>\n                \n                        \n          <h2 data-jumplink=\"true\">About VGER<\/h2>\n        <p>Vanderbilt Genome Editing Resource (VGER), formerly known as the Transgenic Mouse\/ES Cell Shared Resource, has been a trusted and invaluable resource specializing in generating unique mouse and iPSC lines, cryopreservation, and rederivation for 30 years. VGER also manages the <a href=\"https:\/\/medschool.vanderbilt.edu\/vcmr\/\" target=\"_blank\" rel=\"noopener\">Vanderbilt Cryopreserved Mouse Repository<\/a> (VCMR) a unique resource of genetically engineered mouse models donated by Vanderbilt investigators.<\/p>If you&#8217;re interested in partnering with VGER, our team brings years of expertise in creating novel transgenic mouse models and delivering full\u2011service genome editing for human pluripotent stem cells. We&#8217;d be happy to discuss how we can support your research project.\n <!-- rich-text -->\n          <h2 data-jumplink=\"true\">Mission and Oversight<\/h2>\n        <p>The Vanderbilt Genome Editing Resource (VGER) exists to support scientific discovery by enabling the production and sharing of genetically-altered research models. VGER operates under the oversight of the Vanderbilt Center for Stem Cell Biology, a faculty advisory committee, the Vanderbilt Ingram Cancer Center Shared Resource Oversight Group, and the Center for Basic Sciences.<\/p>\n <!-- rich-text -->\n                        <a href=\"https:\/\/medschool.vanderbilt.edu\/vger\/staff\/\" target=\"_self\">\n                <h3>Our Team<\/h3>\n          <\/a>\n                  <a href=\"https:\/\/medschool.vanderbilt.edu\/vger\/contact-us\/\" target=\"_self\">\n                <h3>Contact Information<\/h3>\n          <\/a>\n\n","protected":false},"excerpt":{"rendered":"<p>IMPACT &gt;230 CRISPR-edited alleles 20 sgRNA expression models (CRISPRi) 4 CRISPR-edited hPSCs 4 sgRNA array models (iMAP) &gt;1,100 mouse lines cryopreserved &gt;540 mouse lines rederived 750 gene targeted alleles &gt;2800 transgenic founder mice 83 VCMR strains .max-message { display: block; margin: 0 4px; padding: 10px 0; font-style: italic; } .factoids__description{ margin-bottom: 18px; } .factoids__description p, [&hellip;]<\/p>\n","protected":false},"author":314,"featured_media":125,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-315","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"ACF":{"topper_style":"alternate","topper_overline":"","topper_title":"","topper_intro":"<div>The Vanderbilt Genome Editing Resource (VGER) empowers discovery by creating, preserving, and sharing cutting\u2011edge genetically engineered mouse and stem cell models. 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