VISP Publication Updates

February 16, 2016

Two VISP students have recently been listed as co-authors in new publications.

Pedro Garcia Barrantes, a fourth year student in Dr. Craig Lindsley's lab, was listed as first-author on two publications and co-author on a third:

Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core.
Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW. 
Bioorganic and Medicinal Chemistry Letters (2015), Vol. 25(22), 5107-10. 
PMID: 26476971

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.
Garcia-Barrantes PM, Cho HP, Niswender CM, Byers FW, Locuson CW, Blobaum AL, Xiang Z, Rook JM, Conn PJ, Lindsley CW. 
Journal of Medicinal Chemistry (2015), Vol. 58(20), 7959-71. 
PMID: 26426481

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.
Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW. 
ACS Medicinal Chemistry Letters (2015), Vol. 6(6):716-20.
PMID: 26157544

Kim Ramil Montaniel, a third year in Dr. David Harrison's lab, was listed as co-author on two different publications:

The Origin of Matrix-Producing Cells that Contribute to Aortic Fibrosis in Hypertension.
Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG.
Hypertension. 2015 Dec 22. pii: HYPERTENSIONAHA.115.06123. [Epub ahead of print]
PMID: 26693821
 
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.
PMID: 26595812

Congratulations, Pedro and Kim, on your latest publication work!