Kamakoti Bhat

Kamakoti Bhat

Hi, my name is Kamakoti Bhat, but I just go by Kami. I am from Chennai, India. I have a bachelor's degree in Pharmaceutical Biotechnlogy from AC tech, Anna University- Guindy campus. Near the end of my under-graduation, I applied to several colleges in the US and I chose Vanderbilt because I really liked the IGP program. It is a very broad program and it gives me the freedom to really look at each lab individually and the flexibility to choose which department to affiliate to.

I am interested in the basic biology of DNA replication and repair, and how these fundamental processes are deregulated in cancer. At the end of my first year, I chose to enter the lab of Dave Cortez, and the department of Biochemistry.  Human cells possess a signalling network of proteins that sense and repair DNA damage, thereby preserving genomic integrity. In diseases like cancer, many of these proteins are mutated, giving rise to genomic instability. However, this also poses a unique therapeutic opportunity to selectively target cancer cells that have mutations in these proteins. I study SMARCAL1, an integral component of the cellular response to DNA damage.

My hobbies include traveling, and reading.

 

Publications:

Bhat KP, Bétous R, Cortez D.  High-affinity DNA Binding Domains of Replication Protein A (RPA) Direct SMARCAL1-dependent Replication Fork Remodeling.  J Biol Chem. 2014 Dec 31. pii: jbc.M114.627083. [Epub ahead of print]