Vladislava Vlckova (2012)
Country: Czech Republic
VU Mentor: Neil Osheroff
Hello! My name is Vladislava Vlckova and I come from the Czech Republic. I have just finished the first year of my Master studies at Charles University in Prague in field “Molecular biology, genetics and virology”; Bachelor degree I received at the same place. In Prague I work in the Laboratory of Regulation of Gene Expression at the Academy of Sciences of the Czech Republic headed by Leos Valasek, Ph.D., where we are focused mainly on the initiation of translation in eukaryotes. Concerning my master thesis project, it deals with the role of eIF3a in mRNA recruitment in yeasts during translation initiation.
At Vanderbilt University I have joined the laboratory of Neil Osheroff, Ph.D., from department of Biochemistry. This lab is specialized on function and biology of DNA topoisomerases which is very useful for various antibiotic and anticancer drugs development. My summer project will involve the characterization of topoisomerase IV from E.coli and identification of various topoisomerase – drug interactions. It sounds really interesting so far and I am sure it will extend my scientific horizons.
I am really glad I got the chance to participate in VISRA program and I have been enjoying it since the first days. All people we have met here are really nice and all the activities we can attend are very well organized. VISRA gives everybody the opportunity not only to participate in very good research and learn new techniques, but also meet interesting people, visit new places and enjoy fun with other VISRA participants.
Vladislava is a co-author on a paper from her time in the Osherhoff lab:
Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry. 2014 Sep 2;53(34):5558-67. doi: 10.1021/bi500682e. Epub 2014 Aug 21.