My overarching goals are to dissect the relevant genetic regulatory networks, and their interplay with spatiotemporally dynamic intercellular signaling processes, in regulating the processes of pancreas specification, lineage diversification as it interacts with the morphogenetic processes of building the organ, and particularly the ß-cell differentiation program. The knowledge obtained from these studies will improve our understanding of the transcriptional regulatory hierarchies that direct the formation of ß-cells, thus, could be applied to in vitro directed differentiation of human embryonic stem cells to mature ß-cells for transplantation into type I diabetes patients.
Postdoctoral Fellow, Cell & Developmental Biology
VUMC/Stem Cell & Developmental Biology 9465 MRB IVNashville 37232-0494
(615) 343-8258 (lab)