Better identification of pancreatic multipotent progenitor cells, and determination of how they transition to endocrine-biased progenitors will improve in vitro ES cell differentiation protocols, and are therefore of high relevance to the therapeutic control of beta cell regeneration. As a nexus for gene regulatory networks controlling progenitors and beta cell differentiation, Pdx1’s spatiotemporal expression lead to context-dependent interpretations by different progenitors. My research focuses on the in vivo dissection of Pdx1 function, including (1) Requirement and sufficiency of Pdx1 in multipoent and endocrine-biased progenitor cells, and (2) Roles and epigenetic dissection of cis-regulation of Pdx1 via conserved mammal-specific Area II.
Postdoctoral Fellow, Cell & Developmental Biology
VUMC/Stem Cell & Developmental Biology 9465 MRB IVNashville 37232-0494
(615) 343-8258 (lab)