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Targeting MYC through WDR5

Authors

Thomas LR Lance R , Adams CM Clare M , Fesik SW Stephen W , Eischen CM Christine M , Tansey WP William P .
Molecular & cellular oncology. 2020 1 10; 7(2).
1709388

Abstract

The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated – but currently undruggable – anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.

Tags: Publications