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The Vanderbilt Center for
Extracellular Vesicle Research

The Vanderbilt Center for Extracellular Vesicle Research Publications

2024

Smith SC , Krystofiak E , Ogden KM , Mammalian orthoreovirus can exit cells in extracellular vesicles PLoS pathogens. 2024 Jan 11; 20 (1). e1011637
Ransom MA , Blatt AM , Pua HH , Sucre JMS , The emerging role of extracellular vesicles in bronchopulmonary dysplasia American journal of physiology. Lung cellular and molecular physiology. 2024 Mar 12; 326 (5). L517-L523
von Lersner AK , Fernandes F , Ozawa PMM , Jackson M , Masureel M , Ho H , Lima SM , Vagner T , Sung BH , Wehbe M , Franze K , Pua H , Wilson JT , Irish JM , Weaver AM , Di Vizio D , Zijlstra A , Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution ACS nano. 2024 Apr 05; 18 (15). 10464-10484
Chen HC , Wang J , Coffey RJ , Patton JG , Weaver AM , Shyr Y , Liu Q , EVPsort: An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles Journal of molecular biology. 2024 Apr 10; 168571
Maniya NH , Kumar S , Franklin JL , Higginbotham JN , Scott AM , Gan HK , Coffey RJ , Senapati S , Chang HC , An anion exchange membrane sensor detects EGFR and its activity state in plasma CD63 extracellular vesicles from patients with glioblastoma Communications biology. 2024 Jun 03; 7 (1). 677

2023

Tutanov OS , Glass SE , Coffey RJ , Emerging connections between GPI-anchored proteins and their extracellular carriers in colorectal cancer Extracellular vesicles and circulating nucleic acids. 2023 May 18; 4 (2). 195-217
Barman B , Ramirez M , Dawson TR , Liu Q , Weaver AM , Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A Proteomics. 2023 Nov 05; 24 (11). e2300099
Jimenez L , Stolzenbach V , Ozawa PMM , Ramirez-Solano M , Liu Q , Sage J , Weaver AM , Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells Proteomics. 2023 Nov 05; 24 (11). e2300030
Anyika T , Hong I , Ndukaife JC , Mirror-Enhanced Plasmonic Nanoaperture for Ultrahigh Optical Force Generation with Minimal Heat Generation Nano letters. 2023 Nov 21; 23 (24). 11416-11423
Smith SC , Krystofiak E , Ogden KM , Mammalian orthoreovirus can exit cells in extracellular vesicles bioRxiv : the preprint server for biology. 2023 Aug 29;
Hong I , Hong C , Tutanov OS , Massick C , Castleberry M , Zhang Q , Jeppesen DK , Higginbotham JN , Franklin JL , Vickers K , Coffey RJ , Ndukaife JC , Anapole-Assisted Low-Power Optical Trapping of Nanoscale Extracellular Vesicles and Particles Nano letters. 2023 Aug 08; 23 (16). 7500-7507
Hong C , Ndukaife JC , Scalable trapping of single nanosized extracellular vesicles using plasmonics Nature communications. 2023 Aug 09; 14 (1). 4801
Jeppesen DK , Zhang Q , Franklin JL , Coffey RJ , Extracellular vesicles and nanoparticles: emerging complexities Trends in cell biology. 2023 Feb 01; 33 (8). 667-681
Barman B , Ramirez M , Dawson TR , Liu Q , Weaver AM , Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A bioRxiv : the preprint server for biology. 2023 Jul 19;
Dixson AC , Dawson TR , Di Vizio D , Weaver AM , Context-specific regulation of extracellular vesicle biogenesis and cargo selection Nature reviews. Molecular cell biology. 2023 Feb 10; 24 (7). 454-476
Wang J , Chen HC , Sheng Q , Dawson TR , Coffey RJ , Patton JG , Weaver AM , Shyr Y , Liu Q , Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles Cancers. 2023 Jun 30; 15 (13).
LaPlante EL , Stürchler A , Fullem R , Chen D , Starner AC , Esquivel E , Alsop E , Jackson AR , Ghiran I , Pereira G , Rozowsky J , Chang J , Gerstein MB , Alexander RP , Roth ME , Franklin JL , Coffey RJ , Raffai RL , Mansuy IM , Stavrakis S , deMello AJ , Laurent LC , Wang YT , Tsai CF , Liu T , Jones J , Van Keuren-Jensen K , Van Nostrand E , Mateescu B , Milosavljevic A , exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers Cell genomics. 2023 Apr 20; 3 (5). 100303
Cable J , Witwer KW , Coffey RJ , Milosavljevic A , von Lersner AK , Jimenez L , Pucci F , Barr MM , Dekker N , Barman B , Humphrys D , Williams J , de Palma M , Guo W , Bastos N , Hill AF , Levy E , Hantak MP , Crewe C , Aikawa E , Adamczyk AM , Zanotto TM , Ostrowski M , Arab T , Rabe DC , Sheikh A , da Silva DR , Jones JC , Okeoma C , Gaborski T , Zhang Q , Gololobova O , Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report Annals of the New York Academy of Sciences. 2023 Mar 18; 1523 (1). 24-37
Zhang Q , Jeppesen DK , Higginbotham JN , Franklin JL , Coffey RJ , Comprehensive isolation of extracellular vesicles and nanoparticles Nature protocols. 2023 Mar 13; 18 (5). 1462-1487
Dawson TR , Weaver AM , Niche tension controls exosome production Nature cell biology. 2023 Mar 25; 25 (3). 377-378
Ransom MA , Bunn KE , Negretti NM , Jetter CS , Bressman ZJ , Sucre JMS , Pua HH , Developmental trajectory of extracellular vesicle characteristics from the lungs of preterm infants American journal of physiology. Lung cellular and molecular physiology. 2023 Jan 31; 324 (3). L385-L392
Sung BH , Weaver AM , Visualization of Exosome Release and Uptake During Cell Migration Using the Live Imaging Reporter pHluorin_M153R-CD63 Methods in molecular biology (Clifton, N.J.). 2023 ; 2608 83-96

2022

Schwager SC , Young KM , Hapach LA , Carlson CM , Mosier JA , McArdle TJ , Wang W , Schunk C , Jayathilake AL , Bates ME , Bordeleau F , Antonyak MA , Cerione RA , Reinhart-King CA , Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis eLife. 2022 Dec 07; 11
Zhang C , Huo X , Zhu Y , Higginbotham JN , Cao Z , Lu X , Franklin JL , Vickers KC , Coffey RJ , Senapati S , Wang C , Chang HC , Electrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins Communications biology. 2022 Dec 10; 5 (1). 1358
Glass E , Coffey J , Recent Advances in the Study of Extracellular Vesicles in Colorectal Cancer Gastroenterology. 2022 Jun 20;
Salomon Carlos , Das Saumya , Erdbrügger Uta , Kalluri Raghu , Lim Kiang , Olefsky M , Rice E , Sahoo Susmita , Tao Andy , Vader Pieter , Wang Qun , Weaver M , Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement Endocr Rev. 2022 Apr 21;
Michell L , Allen M , Cavnar B , Contreras M , Yu Minshi , Semler M , Massick Clark , Raby A , Castleberry Mark , Ramirez A , Zhu Wanying , May-Zhang Linda , Ifrim Anca , Carr Jeffrey , Terry G , Schwendeman Anna , Davies S , Sheng Quanhu , Linton F , Vickers C , Elucidation of physico-chemical principles of high-density lipoprotein-small RNA binding interactions J Bill Chem.. 2022 Apr 18;
Barman Bahnisikha , Sung Bong Hwan , Krystofiak Evan , Ping Jie , Ramirez Marisol , Millis Bryan , Allen Ryan , Prasad Nripesh , Chetyrkin Sergei , Calcutt M Wade , Vickers Kasey , Patton G , Liu Qi , Weaver Alissa , VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites Developmental Cell. 2022 Apr 7;
Ochieng Josiah , Korolkova Y , Li Guoliang , Jin Renjie , Chen Zhenbang , Matusik J , Adunyah Samuel , Sakwe M , Ogunkua Olugbemiga , Fetuin-A Promotes 3-Dimensional Growth in LNCaP Prostate Cancer Cells by Sequestering Extracellular Vesicles to Their Surfaces to Act as Signaling Platforms International Journal of Molecular Sciences. Int J Mol Sci. 2022 Apr 5;

2021

Abner Jessica J , Franklin Jeffrey L , Clement Margaret A , Hinger Scott A , Allen Ryan M , Liu Xiao , Kellner Stefanie , Wu Junzhou , Karijolich John , Liu Qi , Vickers Kasey C , Dedon Peter , Weaver Alissa M , Coffey Robert J , Patton James G , Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m 6 A consensus sequences Heliyon. 2021 Dec 2;
Sanchez Greg Berumen , Bunn Kaitlyn E , Pua Heather H , Rafat Marjan , Extracellular vesicles: mediators of intercellular communication in tissue injury and disease 2021 Oct 16;
Nation Grant , Saffold Cherie , Pua H , Secret messengers: Extracellular RNA communication in the immune system 2021 Sep 20;
Chanaday Natali , Kavalali Ege , Synaptobrevin-2 dependent regulation of single synaptic vesicle endocytosis 2021 Jun 30;
Lim Aaron , Vincent Benjamin , Weaver Alissa , Rathmell W Kimryn , Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma 2021 Jun 4;
Sung Bong Hwan , Parent Carole , Weaver Alissa , Extracellular vesicles: Critical players during cell migration 2021 Apr 2;
Chanaday Natali , Nosyreva Elena , Shin Ok-Ho , Zhang Hua , Aklan Iltan , Atasoy Deniz , Bezprozvanny Ilya , Kavalali Ege , Presynaptic store-operated Ca 2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress 2021 Mar 4;
Patel Mikin , Weaver Alissa , Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling 2021 Mar 9;
Vilcaes A Alejandro , Chanaday Natali L , Kavalali Ege T , Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles 2021 Jan 20;

2020

Benjamin John , Plosa Erin , Sucre Jennifer , van der Meer Riet , Dave Shivangi , Gutor Sergey , Nichols David , Gulleman Peter , Jetter Christopher , Han Wei , Xin Matthew , Dinella Peter , Catanzarite Ashley , Kook Seunghyi , Dolma Kalsang , Lal Charitharth , Gaggar Amit , Blalock J Edwin , Newcomb Dawn , Richmond Bradley , Kropski Jonathan , Young Lisa , Guttentag Susan , Blackwell Timothy , Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD 2020 Oct 27;
Altei Wanessa , Pachane Bianca , Dos Santos Patty , Ribeiro Lígia , Hwan Sung Bong , Weaver Alissa , Selistre-de-Araújo Heloisa , Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles 2020 Sep 29;
Hinger Scott , Abner Jessica , Franklin Jeffrey , Jeppesen Dennis , Coffey Robert , Patton James , Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells 2020 Sep 26;
Didiano Dominic , Abner Jessica , Hinger Scott , Flickinger Zachary , Kent Matthew , Clement Margaret , Balaiya Sankarathi , Liu Qi , Dai Xiaozhuan , Levine Edward , Patton James , Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles 2020 Sep 22;
Mariscal Javier , Vagner Tatyana , Kim Minhyung , Zhou Bo , Chin Andrew , Zandian Mandana , Freeman Michael , You Sungyong , Zijlstra Andries , Yang Wei , Di Vizio Dolores , Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles 2020 Sep 18;
Wong Sara , Hepowit Nathaniel , Port Sarah , Yau Richard , Peng Yutian , Azad Nadia , Habib Alim , Harpaz Nofar , Schuldiner Maya , Hughson Frederick , MacGurn Jason , Weisman Lois , Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor 2020 Sep 11;
Korolkova Olga , Widatalla Sarrah , Williams Stephen , Whalen Diva , Beasley Heather , Ochieng Josiah , Grewal Thomas , Sakwe Amos , Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies 2020 Aug 14;
Lim Aaron , Rathmell W Kimryn , Rathmell Jeffrey , The Tumor Microenvironment as a Metabolic Barrier to Effector T Cells and Immunotherapy Elife. 2020 May 5;
Sung Bong Hwan , von Lersner Ariana , Guerrero Jorge , Krystofiak Evan , Inman David , Pelletier Roxanne , Zijlstra Andries , Ponik Suzanne , Weaver Alissa , A Live Cell Reporter of Exosome Secretion and Uptake Reveals Pathfinding Behavior of Migrating Cells Nat Commun.. 2020 Apr 29; 11 (1).
Tumolo JM , Hepowit NL , Joshi SS , MacGurn JA , A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast PLoS genetics. 2020 Mar 19; 16 (3). e1008677

2019

Weaver AM , Patton JG , Argonautes in Extracellular Vesicles: Artifact or Selected Cargo? Cancer research. 2019 Nov 29; 80 (3). 379-381
Zaborowski MP , Cheah PS , Zhang X , Bushko I , Lee K , Sammarco A , Zappulli V , Maas SLN , Allen RM , Rumde P , György B , Aufiero M , Schweiger MW , Lai CP , Weissleder R , Lee H , Vickers KC , Tannous BA , Breakefield XO , Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles Scientific reports. 2019 Nov 22; 9 (1). 17387
Postema MM , Grega-Larson NE , Meenderink LM , Tyska MJ , PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli Molecular biology of the cell. 2019 Aug 07; 30 (19). 2515-2526
Schwager SC , Bordeleau F , Zhang J , Antonyak MA , Cerione RA , Reinhart-King CA , Matrix stiffness regulates microvesicle-induced fibroblast activation American journal of physiology. Cell physiology. 2019 Apr 24; 317 (1). C82-C92
Jimenez L , Yu H , McKenzie AJ , Franklin JL , Patton JG , Liu Q , Weaver AM , Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs Journal of proteome research. 2019 Jan 23; 18 (3). 947-959
Pua HH , Happ HC , Gray CJ , Mar DJ , Chiou NT , Hesse LE , Ansel KM , Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses Cell reports. 2019 Jan 22; 26 (4). 933-944.e4
Das S , , Ansel KM , Bitzer M , Breakefield XO , Charest A , Galas DJ , Gerstein MB , Gupta M , Milosavljevic A , McManus MT , Patel T , Raffai RL , Rozowsky J , Roth ME , Saugstad JA , Van Keuren-Jensen K , Weaver AM , Laurent LC , The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research Cell. 2019 Apr 4; 177 (2). 231-242
Jeppesen DK , Fenix AM , Franklin JL , Higginbotham JN , Zhang Q , Zimmerman LJ , Liebler DC , Ping J , Liu Q , Evans R , Fissell WH , Patton JG , Rome LH , Burnette DT , Coffey RJ , Reassessment of Exosome Composition Cell. 2019 Apr 4; 177 (2). 428-445.e18
Zhang Q , Higginbotham JN , Jeppesen DK , Yang YP , Li W , McKinley ET , Graves-Deal R , Ping J , Britain CM , Dorsett KA , Hartman CL , Ford DA , Allen RM , Vickers KC , Liu Q , Franklin JL , Bellis SL , Coffey RJ , Transfer of Functional Cargo in Exomeres Cell reports. 2019 Apr 04; 27 (3). 940-954.e6
Engevik AC , Kaji I , Postema MM , Faust JJ , Meyer AR , Williams JA , Fitz GN , Tyska MJ , Wilson JM , Goldenring JR , Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes The Journal of cell biology. 2019 Sep 27; 218 (11). 3647-3662
Sato S , Vasaikar S , Eskaros A , Kim Y , Lewis JS , Zhang B , Zijlstra A , Weaver AM , EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling JCI insight. 2019 Oct 29;

2018

Ochieng J , Nangami G , Sakwe A , Moye C , Alvarez J , Whalen D , Thomas P , Lammers P , Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes International journal of molecular sciences. 2018 Jul 29; 19 (8).
Sato S , Weaver AM , Extracellular vesicles: important collaborators in cancer progression Essays in biochemistry. 2018 May 15; 62 (2). 149-163
Sung BH , Weaver AM , Directed migration: Cells navigate by extracellular vesicles The Journal of cell biology. 2018 Jul 05; 217 (8). 2613-2614
Rojas JD , Papadopoulou V , Czernuszewicz TJ , Rajamahendiran RM , Chytil A , Chiang YC , Chong DC , Bautch VL , Rathmell WK , Aylward S , Gessner RC , Dayton PA , Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma IEEE transactions on bio-medical engineering. 2018 Jul 27; 66 (3). 873-880
Vagner T , Spinelli C , Minciacchi VR , Balaj L , Zandian M , Conley A , Zijlstra A , Freeman MR , Demichelis F , De S , Posadas EM , Tanaka H , Di Vizio D , Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma Journal of extracellular vesicles. 2018 Aug 07; 7 (1). 1505403
Allen RM , Zhao S , Ramirez Solano MA , Zhu W , Michell DL , Wang Y , Shyr Y , Sethupathy P , Linton MF , Graf GA , Sheng Q , Vickers KC , Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins Journal of extracellular vesicles. 2018 Aug 13; 7 (1). 1506198
Reis-Sobreiro M , Chen JF , Novitskaya T , You S , Morley S , Steadman K , Gill NK , Eskaros A , Rotinen M , Chu CY , Chung LWK , Tanaka H , Yang W , Knudsen BS , Tseng HR , Rowat AC , Posadas EM , Zijlstra A , Di Vizio D , Freeman MR , Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential Cancer research. 2018 Aug 28; 78 (21). 6086-6097
Ochieng J , Nangami G , Sakwe A , Rana T , Ingram S , Goodwin JS , Moye C , Lammers P , Adunyah SE , Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4 FEBS letters. 2018 Sep 20; 592 (19). 3274-3285
Maacha S , Hong J , von Lersner A , Zijlstra A , Belkhiri A , AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking Neoplasia (New York, N.Y.). 2018 Sep 03; 20 (10). 1008-1022
Hinger SA , Cha DJ , Franklin JL , Higginbotham JN , Dou Y , Ping J , Shu L , Prasad N , Levy S , Zhang B , Liu Q , Weaver AM , Coffey RJ , Patton JG , Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells Cell reports. 2018 Oct 16; 25 (3). 715-725.e4

2017

Petrova RS , Webb KF , Vaghefi E , Walker K , Schey KL , Donaldson PJ , Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells American journal of physiology. Cell physiology. 2017 Nov 08; 314 (2). C191-C201

Jimenez L , Barman B , Jung YJ , Cocozza L , Krystofiak E , Saffold C , Vickers KC , Wilson JT , Dawson TR , Weaver AM , Culture conditions greatly impact the levels of vesicular and extravesicular Ago2 and RNA in extracellular vesicle preparations Journal of extracellular vesicles. ; 12 (11). e12366
Welsh JA , Goberdhan DCI , O'Driscoll L , Buzas EI , Blenkiron C , Bussolati B , Cai H , Di Vizio D , Driedonks TAP , Erdbrügger U , Falcon-Perez JM , Fu QL , Hill AF , Lenassi M , Lim SK , Mahoney MG , Mohanty S , Möller A , Nieuwland R , Ochiya T , Sahoo S , Torrecilhas AC , Zheng L , Zijlstra A , Abuelreich S , Bagabas R , Bergese P , Bridges EM , Brucale M , Burger D , Carney RP , Cocucci E , Crescitelli R , Hanser E , Harris AL , Haughey NJ , Hendrix A , Ivanov AR , Jovanovic-Talisman T , Kruh-Garcia NA , Ku'ulei-Lyn Faustino V , Kyburz D , Lässer C , Lennon KM , Lötvall J , Maddox AL , Martens-Uzunova ES , Mizenko RR , Newman LA , Ridolfi A , Rohde E , Rojalin T , Rowland A , Saftics A , Sandau US , Saugstad JA , Shekari F , Swift S , Ter-Ovanesyan D , Tosar JP , Useckaite Z , Valle F , Varga Z , van der Pol E , van Herwijnen MJC , Wauben MHM , Wehman AM , Williams S , Zendrini A , Zimmerman AJ , , Théry C , Witwer KW , Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches Journal of extracellular vesicles. ; 13 (2). e12404
Wang-Bishop L , Wehbe M , Shae D , James J , Hacker BC , Garland K , Chistov PP , Rafat M , Balko JM , Wilson JT , Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma Journal for immunotherapy of cancer. ; 8 (1).
Zijlstra A , Di Vizio D , Size matters in nanoscale communication Nature cell biology. ; 20 (3). 228-230