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The Vanderbilt Center for
Extracellular Vesicle Research

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report

AUTHORS

Cable J , Witwer KW , Coffey RJ , Milosavljevic A , von Lersner AK , Jimenez L , Pucci F , Barr MM , Dekker N , Barman B , Humphrys D , Williams J , de Palma M , Guo W , Bastos N , Hill AF , Levy E , Hantak MP , Crewe C , Aikawa E , Adamczyk AM , Zanotto TM , Ostrowski M , Arab T , Rabe DC , Sheikh A , da Silva DR , Jones JC , Okeoma C , Gaborski T , Zhang Q , Gololobova O , . Annals of the New York Academy of Sciences. 2023 03 18; 1523(1). 24-37

ABSTRACT

Extracellular vesicles (EVs) are small, lipid-bilayer-bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally as well as to distant tissues to coordinate tissue homeostasis and systemic responses. There is a growing interest in not only understanding the physiology of EVs as signaling particles but also leveraging them as minimally invasive diagnostic and prognostic biomarkers (e.g., they can be found in biofluids) and drug-delivery vehicles. On October 30-November 2, 2022, researchers in the EV field convened for the Keystone symposium “Exosomes, Microvesicles, and Other Extracellular Vesicles” to discuss developing standardized language and methodology, new data on the basic biology of EVs and potential clinical utility, as well as novel technologies to isolate and characterize EVs.