Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles
AUTHORS
Altei
Wanessa ,
Pachane
Bianca ,
Dos Santos
Patty ,
Ribeiro
Lígia ,
Hwan Sung
Bong ,
Weaver
Alissa ,
Selistre-de-Araújo
Heloisa ,
. . 2020 9 29; ().
- PMID: 32988382 [PubMed].
- PMCID: PMC7520983.
ABSTRACT
Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors are enriched in small EVs (SEVs) and SEV-carried integrins have been shown to promote cancer cell migration and to mediate organ-specific metastasis; however, how integrins mediate these effects is not entirely clear and could represent a combination of EV binding to extracellular matrix and cells.