Our main research interest is focused on the nutritional aspects of patients with renal failure. These patients include the ones with chronic kidney disease who are not yet on dialysis, end-stage renal failure (ESRD) patients on different forms of renal replacement therapy such as chronic hemodialysis (CHD), peritoneal dialysis (PD) and kidney transplant, and patients with acute renal failure. Multiple studies have shown that protein-caloric malnutrition (PCM) is associated with increased risk of morbidity and mortality in renal failure patients. This wide spectrum of patients uniformly displays signs and symptoms of PCMin a unique pattern, which can be termed as Uremic Malnutrition. One of our research goals is to identify reliable and practical markers of nutritional status in renal failure patients to better understand the extent of uremic malnutrition. We utilize multiple techniques such as labeled isotope studies (deuterium oxide, sodium bromide, labeled urea) as well as multifrequency bioelectrical impedance analysis, dual-energy x-ray absorptiometry and air-displacement plethysmography to study the nutritional status of renal failure patients. Our laboratory is also interested in exploring the factors that predispose renal failure patients to uremic malnutrition. For this purpose, we are performing studies using stable isotope kinetic methodology to examine protein and energy homeostasis in renal failure patients. We also utilize these techniques to assess the metabolic response to several preventive and interventional treatment strategies aimed at improving the nutritional status of renal failure patients.