Publications

Latest Publications

• Identification of KLHL12 Ligands Using Fragment-Based Methods. Journal of Medicinal Chemistry.

  Alex Waterson*, Anish Vadukoot, Somnath Jana, Jianwen Cui, Kelvin Luong, Tyson Rietz, Ezequiel Alejandro Madrigal-Carrillo, Brian Lehmann, John Sensintaffar, Bin Zhao, Kangsa Amporndanai, Zoe Petros, William Scaggs, Selena Chacon Simon, Rakesh Vekariya, Kwangho Kim, Manikandan Thangaraj, Plamen Christov, Taylor South, Jiqing Sai, Anusha Thiruvaipati, Edward Olejniczak, Jason Phan, Stephen Fesik*.
  
  Supported by the Biomolecular NMR Facility and the High-Throughput Screening Facility.

  5-Azacytidine incorporation into mRNAs disrupts translation and induces ribosome collisions (preprint). bioRxiv. Alexis Roberson*, James Marks*, Ruby Pitts, Bavavarshini Tamilselvam, Brian Grieb, William Tansey, Sezen Meydan*.

  Spirocyclic β-lactone secondary metabolites modulate spliceosome function. Proceedings of the National Academy of Sciences. Kathryn Penton*, Sydney Bates, Hannah Thirman, Crissey Cameron, Christopher Jurich, Ming Jiang, Michael Savona, Zhongyue Yang, Lars Plate, Jonathan Irish, Brian Bachmann*.

  Expression and purification of Steroidogenic Factor-1 (NR5A1) nuclear receptor ligand binding domain complexed with the signaling phosphoinositide lipid PI(3,4,5)P₃. Campbell AN, Cutright AJ, Martin J, Kheda A, Loi MNC, Blind RD.

  Unusual and atypical cyclooxygenase reactions. Schneider C, Brash AR.

  
  Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress. Hu R, Wang Y, Yagan M, Xu Y, Simmons AJ, Lau KS, Liu Q, Gu G.

  
  A requirement for Acinetobacter baumannii purine biosynthesis during lung infection is exacerbated by host zinc deficiency. Palmer LD, Noel HR, Traina KA, Geary JH, Skaar EP.

  
  The scientific legacy of Martin Karplus from the perspective of his collaborators.

  Andricioaei I, Best RB, Birge RR, Boresch S, Brunger A, Brooks BR, Buck M, Brüschweiler R, Caflisch A, Case DA, Cui Q, Dejaegere A, Dinner AR, Elber R, Evanseck JD, Gao J, Guo H, Hubbard RE, Kuriyan J, Joseph-McCarthy D, Levy RM, Nilsson L, Mattos C, MacKerell AD Jr, McCammon JA, Michnick SW, Mulholland A, Meuwly M, Pastor RW, Reuter N, Roux B, Sali A, Schlick T, Smith JC, Stote RH, Straub JE, Taly A, van der Vaart A, Wan S, Weiss MA, Yang W, York DM, Zhou Y.

  
  Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease. Spencer PN, Brown ME, Smith EP, Wang J, Kim W, Spiga L, Tasneem N, Simmons AJ, Kim T, Yang Y, Xu Y, Zheng L, Ro J, Kaur H, Kang SW, Helou MD, Lee MA, Arceneaux D, Mueller KD, Kuddar OS, Harned MH, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Washington MK, Valdivia RH, Zhu W, Lau KS.

  Serotonin Expression and β-Cell Phenotype Are Associated With Indolent Behavior in Pancreatic Neuroendocrine Tumors With Sclerosing Morphology. Windon AL, Revetta F, Chen W, Shi C.