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Latest Publications
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Classification models for KCNQ1 variants distinguish functional and trafficking effects to enhance pathogenicity interpretation. Proceedings of the National Academy of Sciences.
Ana Chang-Gonzalez*, Eric Bell, Kathryn Butcher, James Scott, Charles Sanders, Kaitlyn Ledwitch, Jens Meiler*.Multimodal Imaging of the Cellular and Extracellular Microenvironment on the Same Formalin-Fixed Paraffin-Embedded Tissue Section (preprint). bioRxiv.
Jade Macdonald*, Thai Pham, Alan Simmons, Harsimran Kaur, Jamie Allen, Anna Smith, Audra Judd, Seung Woo Kang, Madeline Colley, Melissa Farrow, Ken Lau, Jeffrey Spraggins*.A Gata4–Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish. Cell Reports.
Nicolas Noel*, Andrew Kjar, Paige Pfotenhauer, Hyosung Kim, Ethan Lippmann, Valentina Cigliola*.Supported by the Cell Imaging Shared Resource.
Tuning Vibrational Coupling Strength Between Hyperbolic Media and Organic Molecules. Nanophotonics.
Ragle CL, Buchner JE, Lee IH, Kim Y, Noh BI, Dixit S, Matson J, Li J, Dai S, Edgar JH, Oh SH, Buchanan LE, Caldwell JD.
Fragment-based drug discovery strategy reveals an unprecedented allosteric binding site in Mycobacterium tuberculosis DNA gyrase. Eur J Med Chem.
Shiroma ST, Rossini NO, Armenia JF, Silva CS, Souza PCT, Coureux PD, Osheroff N, Dias MVB.Hepatic FoxO1 loss leads to pancreatic β cell deficiency via liver-derived C18/22/24 ceramides. Cell Chem Biol.
Gong Y, Lu Q, Li X, Han G, Ma X, Liu Y, Xi L, Wang C, Zhai G, Zhang Z, Liu H, Jin J, Yang Y, Zhu X, Yin Z, Sun Y, Chen W, Xie S, Han D.Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer. Cancer Med.
Harmych SJ, Singh B.
LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation. Proc Natl Acad Sci U S A.
Ren H, Lee HR, Omar YAD, DeGrandchamp JB, Hung CL, Eisen TJ, Stamou D, Kuriyan J, Chakraborty AK, Groves JT.Multimodal Imaging of the Cellular and Extracellular Microenvironment on the Same Formalin-Fixed Paraffin-Embedded Tissue Section. bioRxiv [Preprint].
Macdonald JK, Pham T, Simmons AJ, Kaur H, Allen JL, Smith AJ, Judd AM, Kang SW, Colley ME, Farrow MA, Lau KS, Spraggins JM.Potently neutralizing and protective human monoclonal antibodies against the measles fusion protein trimer. Cell Rep Med.
Handal LS, Binshtein E, Kose N, Suryadevara N, Zost SJ, Trivette A, Peng KW, Quinn B, Ravera S, Menghini MT, Kona C, Martinez J, Rutherford SA, Blanco JCG, Boukhvalova MS, Muñoz-Alía MÁ, Crowe JE Jr.N-aldehyde modified phosphatidylethanolamines formed by lipid peroxidation inhibit efferocytosis (preprint). bioRxiv.
Reza Fadaei*, Annie Bernstein, Elizabeth Wayman, Azuah Gonzalez, Keri Tallman, Zahra Mashhadi, Abdul-Musawwir Alli-Oluwafuyi, Sergey Dikalov, MacRae Linton, Kasey Vickers, Amanda Doran, Sean Davies*.Drug repurposing identifies candidate uterus-selective tocolytics for preterm labor. Science Translational Medicine.
Shajila Siricilla*, Christopher Hansen, Jeremy Staub, Jordan Walker, Alexus Brown, Sydney Cole, Debasmita De, Lauren Hatcher, Carolyn Simpson, Jackson Rogers, Naoko Boatwright, Stacey Crockett, Deanna Sekulich, Christian Meyer, Vito Quaranta, Quanhu Sheng, John Benjamin, J. M. Newton, Bibhash Paria, Jeff Reese, Jennifer Herington*.Supported by the High-Throughput Screening Facility.
Nitro-arachidonic acid inhibits prostaglandin endoperoxide H synthase 2 through histidine-mediated heme-binding conformational perturbation. Archives of Biochemistry and Biophysics.
Irene Wood* (Universidad de la República), Michael Goodman, Lawrence Marnett.