Publications

Latest Publications

• Optimization of Pyrazole-Based Activators of Kv3.1. ACS Medicinal Chemistry Letters.
  Paul Spearing*, Vaishali Satpute Janke, Ian Romaine, Navoda Jayakodiarachchi, Benjamin Guttentag, Somnath Jana, Kwangho Kim, Jerod Denton, Craig Lindsley, Alex Waterson*.

  Supported by the Biomolecular NMR Facility and the High-Throughput Screening Facility.

  Heat shock factor 1 signaling: A novel pathway implicated in Rett syndrome pathophysiology. The Journal of Pharmacology and Experimental Therapeutics.
  Sonia Gonzalez* (Loyola University Chicago), Colleen Niswender.

  Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's Disease. ACS Chemical Neuroscience.
  Alexa Richardson*, Anthony Ferranti, Li Peng, Xia Lei, Allie Han, Aidong Qi, Alice Rodriguez, Sichen Chang, Snehal Sant, Irene Zagol-Ikapitte, Srinivasan Krishnan, Analisa Thompson Gray, Joshua Wilkinson, Sri Kethanapalli, Hyekyung Cho, Kayla Temple, Dehui Mi, Emily Days, Joshua Bauer, N. Kithmini Wijesiri, Benjamin Brown, Olivier Boutaud, Carrie Jones, Darren Engers, Craig Lindsley, Colleen Niswender*, Katherine Crocker*.

  Supported by the High-Throughput Screening Facility and the Murine Neurobehavioral Laboratory.

  
  Deep Learning Models Capture Umbrella Sampling-Derived Energetic Trends: A Troponin C Case Study. J Chem Inf Model.
  Narayanasamy A, Moretti R, Meiler J, Lindert S.

  Contributions of conserved and species-specific CagX (VirB9) domains to the assembly and function of the Helicobacter pylori Cag type IV secretion system. Infect Immun.
  Okoye CD, Frick-Cheng AE, Salmen W, Tran SC, McDonald WH, Loh JT, McClain MS, Lacy DB, Ohi MD, Cover TL.

  
  Multiple TonB-dependent transport systems in Helicobacter pylori. Infect Immun.
  Loh JT, Okoye CD, Kunkle DE, McDonald WH, McClain MS, Skaar EP, Cover TL.

  
  Discovery of VU6077564: A Selective M₁ Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons. ACS Chem Neurosci.
  Berida TI, Dodd CJ, Wilkinson JC, Smith DR, Chang S, Presley CC, Peng L, Sant S, Krishnan S, Zagol-Ikapitte I, Watson KJ, Thompson Gray A, Rodriguez AL, Cho HP, Jones CK, Boutaud O, Niswender CM, Engers DW, Fernyhough P, Lindsley CW, Childress ES.

  
  Discovery of VU6066098: A Selective and CNS-Penetrant mGlu₂ NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in Rodents. ACS Chem Neurosci.
  Coleman JS, Capstick RA, Chang S, Rios DJ, Bubser M, Thompson Gray AD, Zagol-Ikapitte I, Krishnan S, Cho HP, Rodriguez AL, Niswender CM, Boutaud O, Garcia GP, Elder GA, Engers DW, Jones CK, Lindsley CW.

  Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors. J Biol Chem.
  Hermanson JN, Hudson AD, Plate L.

  
  FDB&FragLinker: A Large Fragment Database for Rapid Ligand Optimization Within Protein-Ligand Complex. J Mol Biol.
  Zheng L, Zhou Q, Fu T, Peng Y, Dai Y, Chen R, Sun Z, Zhang JZH.

• When the KAT’s away, vulnerability for AML comes out to play. Blood.
  William Tansey.

  Visual arrestin-1: how did we learn what we know today about this protein? Progress in Retinal and Eye Research.
  Vsevolod Gurevich*, Eugenia Gurevich*.

  Discovery of VU6077564: A Selective M₁ Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons. ACS Chemical Neuroscience.
  Tomayo Berida*, Cayden Dodd, Joshua Wilkinson, Sichen Chang, Christopher Presley, Li Peng, Snehal Sant, Srinivasan Krishnan, Irene Zagol-Ikapitte, Katherine Watson, Analisa Thompson Gray, Alice Rodriguez, Hyekyung Cho, Carrie Jones, Olivier Boutaud, Colleen Niswender, Darren Engers, Craig Lindsley, Elizabeth Childress*.

  Repairing Atp10D in C57Bl/6J mice restores protein expression but does not mitigate metabolic stress from high fat diet. Sci Rep.
  Mansueto AJ, Norris AC, Yazlovitskaya EM, Zhu L, Lu J, Koomen DC, May JC, Kim M, Hermanson JN, Molday RS, McLean JA, Plate L, Stafford JM, Graham TR.

  Staphylococcus aureus ZigA is implicated in survival in zinc-deplete and genotoxic environments. Microbiol Spectr. 
  Enriquez KT, Weiss A, Perera YR, Bhatia I, Togashi M, Akizuki T, McDonald WH, Chazin WJ, Skaar EP.

  Fermentative growth decreases the iron demand of Staphylococcus aureus. J Inorg Biochem.
  Boyd JM, Rios-Delgado G, Esquilín-Lebrón K, Kaler KR, Mereddy G, Norambuena J, Zheng V, Beavers WN, Kim J, Parker D, Skaar EP, Carroll RK, Yang JH.

  Automated cGMP Radiosynthesis of [¹⁸F]NOTA-ABY-030 with Aluminum Fluoride on the GE FASTlab Automated Synthesis Platform. Mol Imaging Biol.
  Behof W, Khan I, Grigg J, Jouad K, Cheung YY, Liu F, Illan A, Rosenthal EL, Rosenberg AJ.