Publications

Latest Publications

• • Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility. Chen Z, Song W, Li Q, Li C, Wen W, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Timofeeva MN, Thomas M, Schmit SL, Martin V, Devall M, Dampier C, Moratalla-Navarro F, Cai Q, Wang J, Shi J, Kweon SS, Tanikawa C, Jia WH, Shu X, Long J, Gao J, Kim J, Shin A, Matsuo K, Jee SH, Jung KJ, Wang N, Kim DH, Ping J, Yang G, Shin MH, Ren Z, Oh JH, Oze I, Ahn YO, Gao YT, Pan ZZ, Kamatani Y, Van Kaer L, Wu L, Li B, Matsuda K, Shu XO, Hsu L, Dunlop MG, Gruber SB, Houlston R, Tomlinson I, Li L, Lau KS, Moreno V, Casey G, Peters U, Zheng W, Guo X. Nat Commun. 2026 Jan 15. doi: 10.1038/s41467-025-68127-z. Online ahead of print. PMID: 41540004    
  • Deregulated translation of the transcription factor Myt3 predisposes islet β-cells to dysfunction under obesity-induced metabolic stress. Hu R, Wang Y, Yagan M, Xu Y, Simmons AJ, Lau KS, Liu Q, Gu G. J Biol Chem. 2026 Jan 13:111164. doi: 10.1016/j.jbc.2026.111164. Online ahead of print. PMID: 41539561     
  • Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization. Ankenbauer KE, Yang Y, Chung CY, Andrade LR, Novak SW, Jarvis B, Ali Hanel WH, Liu J, Sarkisian V, Dani N, Krystofiak E, Hu G, Ebrahim S, Kachar B, Gong Q, Wahl GM, Lau KS, Brown JW, Manor U, DelGiorno KE. Cell Mol Gastroenterol Hepatol. 2026 Jan 29:101742. doi: 10.1016/j.jcmgh.2026.101742. Online ahead of print. PMID: 41619969  
  • The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types. Srinivasan J, Moore CR, Calindi A, Helm BR, Yang Y, Moore JF, Selden HJ, Heiser CN, Liu Q, Lau KS, Ehrlich LIR. Nat Immunol. 2026 Feb;27(2):265-280. doi: 10.1038/s41590-025-02371-9. Epub 2026 Jan 8. PMID: 41507389  
  • A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein. Abu-Shmais AA, Guo L, Khalil AM, Leonard SE, Miller RJ, Janke AK, Vukovich MJ, Bass LE, Suresh YP, Rush SA, Wolters RM, Kose N, Carnahan RH, Crowe JE Jr, Bonami RH, Mousa JJ, McLellan JS, Georgiev IS. Cell Rep Med. 2026 Jan 16:102564. doi: 10.1016/j.xcrm.2025.102564. Online ahead of print. PMID: 41547352  
  • Estimating influenza transmission parameters: Comparing two study designs, 2023-2024. Biddle JE, House S, Kwon JH, Presti RM, Fritz SA, Curley T, McLaren SH, Stockwell MS, Schmitz J, Talbot HK, Grijalva CG, Saade EA, Albar Z, Murugan V, Cruz RA, Martin ET, Vaughn IA, Wernli KJ, Wickersham BM, Zimmerman RK, Geffel KM, Gaglani M, Smith ME, Walter EB, Bontrager NAB, Bristol L, Price AM, Chung JR, Flannery B, Rolfes MA, Mellis AM; RVTN-Flu study group, US Flu VE Network Investigators. Epidemics. 2026 Jan 12;54:100888. doi: 10.1016/j.epidem.2026.100888. Online ahead of print. PMID: 41547041   
  • Norepinephrine derepresses the Fur regulon of Neisseria gonorrhoeae to enable growth in iron-limited conditions. Westlake CS, Stoudenmire JL, Bhatia I, Perera YR, Krueger RM, Cornelissen CN, Chazin WJ, Kendall MM, Criss AK. J Bacteriol. 2026 Jan 20:e0059725. doi: 10.1128/jb.00597-25. Online ahead of print. PMID: 41556661   
  • The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair. Kim M, Jeong E, Park J, D'Souza A, Tsai MS, Yan C, Ivanov I, Chazin WJ, Kim HS, Schärer OD. Nucleic Acids Res. 2026 Feb 5;54(4):gkag078. doi: 10.1093/nar/gkag078. PMID: 41641700
  • Deletion of tonB1 in Pseudomonas aeruginosa impairs zinc homeostasis and pathogenicity. Li W, Zheng Y, Wang G, Cheng J, Xiao W, Ma X, Li P, Chazin WJ, Lin J. Appl Environ Microbiol. 2026 Jan 27;92(1):e0197725. doi: 10.1128/aem.01977-25. Epub 2026 Jan 6. PMID: 41493370     
  • CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M. J Chem Inf Model. 2026 Jan 21. doi: 10.1021/acs.jcim.5c02441. Online ahead of print. PMID: 41565251
  • The pathway-independent positive allosteric modulator C1 allows for the identification of active Y4 receptor relevant positions. Schüß C, Vu O, Pelczyk T, Schubert M, Du Y, Stichel J, Weaver CD, Meiler J, Beck-Sickinger AG. Cell Mol Life Sci. 2026 Jan 13;83(1):74. doi: 10.1007/s00018-025-06019-7. PMID: 41528432  
  • Circadian ADCY3 Ser107Pro variant bridges difficulty awakening in the morning and adiposity. Tchio C, Maher M, Moth C, Meiler J, Lane JM, Taylor HA, Williams JS, Saxena R. iScience. 2025 Dec 30;29(2):114587. doi: 10.1016/j.isci.2025.114587. eCollection 2026 Feb 20. PMID: 41630919      
  • Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment. Fisher-Gupta EL, Hathaway ES, Perera JM, Jennings EQ, Chi C, Sewell AE, Stone SH, Muka JE, Sinard RC, DeCorte JA, Chen H, Wilson JT, Meiler J, Rathmell JC. J Immunol. 2026 Jan 21;215(1):vkaf250. doi: 10.1093/jimmun/vkaf250. PMID: 41171699      
  • Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy. Arifova L, MacTavish BS, Laughlin Z, Karadi Girdhar MN, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ. Elife. 2026 Jan 21;14:RP106697. doi: 10.7554/eLife.106697. PMID: 41563829      
  • Deceptive beauty of non-natural structures. Gurevich VV, Gurevich EV. Protein Sci. 2026 Feb;35(2):e70474. doi: 10.1002/pro.70474. PMID: 41562307      
  • RAB25 modulates pit cell commitment by coordinating transforming growth factor-alpha secretion from gastric epithelial cells. Jeong H, Lee Y, Uhm C, Hwang SY, Hur S, Noh M, Coffey RJ, Goldenring JR, Nam KT. Cell Death Dis. 2025 Dec 9;17(1):57. doi: 10.1038/s41419-025-08316-2. PMID: 41365858   
  • Isolation and genomic analysis of secondary metabolism in cave Actinomycetota from biofilms and Ceuthophilus. Bachmann IO, Bachmann BO. MicroPubl Biol. 2026 Jan 4;2026. doi: 10.17912/micropub.biology.001837. eCollection 2026. PMID: 41573672      
  • Structural Basis for how Sialoglycan-binding Viridans Streptococci Accommodate Ligands that Exceed the Characterized Binding Site. Morrison KM, Martin K, Yu H, Chen X, Iverson TM. MicroPubl Biol. 2026 Jan 2;2026. doi: 10.17912/micropub.biology.001838. eCollection 2026. PMID: 41573671      
  • Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan-TAOK Activator. Schultz DC, Parr LC, Sweet H, Lamb S, Engers JL, Napier NC, McKinnie HG, Whomble D, Kramlinger V, Boutaud O, Lindsley CW. ACS Chem Neurosci. 2026 Feb 4;17(3):624-634. doi: 10.1021/acschemneuro.5c00906. Epub 2026 Jan 13. PMID: 41530942  
  • Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2. Haymer DH, Duncan RA, Rodriguez AL, Han A, Lindsay RJ, Wijesiri NK, Thompson Gray A, Krishnan S, Qi A, Brown BP, Boutaud O, Engers DW, Jones CK, Niswender CM, Lindsley CW, Bender AM. J Med Chem. 2026 Feb 5. doi: 10.1021/acs.jmedchem.5c02796. Online ahead of print. PMID: 41642702 
  • Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. Henderson SH, Ringuette AE, Whomble DL, Capstick RA, Richardson AE, Maurer MA, Billard NB, Lei X, Wilkinson JC, Kethanapalli SH, Cho HP, Rodriguez AL, Niswender CM, Peng W, Rook JM, Chang S, Blobaum AL, Boutaud O, Felts AS, Conn PJ, Lindsley CW, Temple KJ. ACS Chem Neurosci. 2026 Jan 25. doi: 10.1021/acschemneuro.5c00896. Online ahead of print. PMID: 41582453    
  • Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy. Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ. ACS Chem Neurosci. 2026 Jan 25. doi: 10.1021/acschemneuro.5c00963. Online ahead of print. PMID: 41581069     
  • Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy. Vermudez SAD, Freitas GA, Smith M, Gogliotti RG, Niswender CM. Neuroscience. 2026 Jan 30:S0306-4522(26)00077-1. doi: 10.1016/j.neuroscience.2026.01.040. Online ahead of print. PMID: 41621618     
  • Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1. Greer BH, Mendia-Garcia J, Mullins EA, Peacock EM, Haigh SK, Schiltz CJ, Aicart-Ramos C, Tsai MS, Cortez D, Moreno-Herrero F, Eichman BF. Nat Commun. 2026 Jan 26. doi: 10.1038/s41467-026-68752-2. Online ahead of print. PMID: 41587991  
  • Enzyme-DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs. Armenia JF, Osheroff N. ACS Infect Dis. 2026 Jan 27. doi: 10.1021/acsinfecdis.5c01018. Online ahead of print. PMID: 41591340   
  • Ambient ionization strategies for the characterization of microbial systems via mass spectrometry. Shepard HS, May JC, McLean JA. Analyst. 2026 Jan 27. doi: 10.1039/d5an01214g. Online ahead of print. PMID: 41590768    Review.
  • An Interlaboratory Comparison of High-Resolution Ion Mobility Collision Cross-Sections from Human Plasma. Harris RA, Zlibut E, Reardon AR, Lira KE, May JC, Stow SM, Williamson DL, Krone J, Kedia K, McLean JA, Strathmann FG. J Am Soc Mass Spectrom. 2026 Feb 4;37(2):522-531. doi: 10.1021/jasms.5c00396. Epub 2025 Dec 29. PMID: 41459920  
  • Disruption of acyl-acyl carrier protein (acyl-ACP) synthetase in cyanobacteria impairs lipid remodeling as revealed by acyl-ACP measurements. Jaroensuk J, Abraham JP, Zuniga BE, Shepard HS, Wei M, Williams R, Morley SA, Lingwan M, Zhou J, Jindra MA, Jyoti P, Wang B, May JC, McLean JA, Young JD, Pfleger BF, Allen DK. Metab Eng. 2026 Mar;94:45-56. doi: 10.1016/j.ymben.2025.11.004. Epub 2025 Nov 5. PMID: 41202967        
  • ER remodelling is a feature of ageing and depends on ER-phagy. Donahue EKF, Hepowit NL, Ruark EM, Mulligan AG, Keuchel B, Urban ND, Peng L, Stephens S, Johnson DJ, Wallace NS, Jackson LP, Ellisman MH, Arrojo E Drigo R, Folkmann AW, Truttmann MC, MacGurn JA, Burkewitz K. Nat Cell Biol. 2026 Feb 2. doi: 10.1038/s41556-025-01860-1. Online ahead of print. PMID: 41629400  
  • Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease. Wei Q, Taylor AJ, Miriyala N, Barmade MA, Gentry ZO, Anderson-Daniels J, Teuscher KB, Crow MM, Apakama C, South TM, Rietz TA, Amporndanai K, Phan J, Sensintaffar JL, Denison M, Lee T, Fesik SW. J Med Chem. 2026 Feb 2. doi: 10.1021/acs.jmedchem.5c03704. Online ahead of print. PMID: 41629155  
  • Genomic adaptation in group B Streptococcus following intrapartum antibiotic prophylaxis and childbirth. Pell ME, Blankenship HM, Gaddy JA, Davies HD, Manning SD. mBio. 2026 Feb 4:e0396625. doi: 10.1128/mbio.03966-25. Online ahead of print. PMID: 41636481