Jonathan Davies
Predoctoral Trainee/ Plate Lab
Dengue virus (DENV) and Zika virus (ZIKV) are two flaviviruses of particularly high public health concern, with currently no effective vaccines or anti-viral therapeutics available. DENV and ZIKV heavily rely on host proteins to facilitate viral replication and hijack cellular homeostasis pathways for pathogenesis, making them susceptible to disruption of host-virus interactions. My project will combine chemical biology tools with quantitative mass spectrometry methods to map host-virus interactomics with temporal resolution during infection, with the aim of identifying potential host factors as therapeutic targets to combat viral pathogenesis.