Executive Committee
Members
Associate Professor of Chemical and Biomolecular Engineering
Associate Professor of Biomedical Engineering
Director of Undergraduate Studies in Chemical Engineering
Professor of Molecular Physiology and Biophysics
Professor of Medicine
Professor of Cell and Developmental Biology
Director, Center for Stem Cell Biology
Research Description
We have a longstanding interest in genes, gene networks, and their regulation. Currently our research is focused on two different gene regulatory networks.
1. Cis-regulatory elements that regulate Sox17. Sox17 is necessary for formation of the hepato-pancreato-biliary (HPB) system emergence of vascular-hematopoietic cells. We are using CRISPR/Cas9-mediated mutagenesis in mice to characterize proximal and distal cis-regulatory elements that control Sox17 expression.
2. Role of Ascl1 in the metabolic stress response of pancreatic beta-cells. Ascl1 is induced by Ca2+-signaling and promotes the expression of genes that control cell identity, proliferation, acetylcholine sensitivity, and parasympathetic innervation. We are using CRISPR inhibition to investigate these genes and the processes they regulate.
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Vanderbilt Faculty Profile
Google Scholar
Publications
: 9475 MRB-IV
2213 Garland Avenue
Nashville, Tennessee - 37232-0494- : mark.magnuson@vanderbilt.edu
- : https://lab.vanderbilt.edu/magnuson-lab/
Associate Professor of Pediatrics
Associate Professor of Cell & Developmental Biology
Professor of Cell & Developmental Biology
Louise B. McGavock Chair
Director, Program in Developmental Biology
Associate Director, Center for Stem Cell Biology