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Vanderbilt Center for Stem Cell Biology (VCSCB)

Gregor Neuert, Ph.D.

Associate Professor of Molecular Physiology and Biophysics
Associate Professor of Biomedical Engineering
Associate Professor of Pharmacology

Research

Quantitative systems biology of dynamic signal transduction and gene regulation in single cells.

In the search for deeper insights into the molecular mechanisms of human diseases, the challenges of capturing the complex and dynamic interplay between cells and their environment remain a pressing concern. While current biological studies often focus on constant environmental conditions, the reality is that the gradual exposure of humans to harmful environmental conditions can have profound effects on signal transduction and gene regulatory pathways, contributing to disease pathogenesis. Moreover, the variability in disease outcomes and response to treatment among individuals with the same condition underscores the need for a more nuanced and single-cell approach to disease research.

To address these limitations, the Neuert lab has set out to shed light on the fundamental mechanisms of signal transduction and gene expression in normal and disease physiology in the context of gradual and physiologically relevant environmental changes and single-cell variability. Employing a quantitative framework to explore a range of biological questions in model organisms and healthy and diseased tissue, the lab integrates a suite of cutting-edge techniques, including single-cell, single-molecule, and genome-wide approaches, with computational data analysis, genetics, molecular biology, chemical profiling, and single-cell predictive computational modeling.

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