Jens Meiler, Ph.D.

Jens Meiler, Ph.D.

Distinguished Research Professor, Chemistry

Areas of Interest: Protein Structure & Function; Computational Biology

Member: CSB; VICC; Center for Matrix Biology

Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind.
A) To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses;
B) Design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.
C) Understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs.

Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.