Molecular Design and Synthesis Center

Genesis glove box is a sealed, inert-atmosphere enclosure for handling air- and moisture-sensitive chemicals and materials. The system maintains very low levels of oxygen and water (typically <1–5 ppm) using continuous purging and/or recirculating purification, allowing safe manipulation of reactive reagents, organometallics, and sensitive intermediates.

A Parr shaker hydrogenator is a bench-scale reactor system for safe and efficient catalytic hydrogenation and related gas–liquid reactions. It uses a sealed reaction bottle mounted on a mechanical shaker to ensure intimate contact between the substrate, catalyst, and hydrogen gas, allowing controlled reductions, deprotections, and other transformations under adjustable pressure and temperature.

A Gilson GX-271 preparative system is a modular high‑performance liquid chromatography (HPLC) platform for large‑scale purification of compounds. It combines high‑capacity pumps, injection modules, UV/other detectors, and automated fraction collectors to separate and collect target molecules (e.g., peptides, natural products, synthetic intermediates) with precise, reproducible control overflow, gradient, and fractionation.

The Agilent 6125B LC/MS is a single quadrupole liquid chromatography–mass spectrometry system for routine qualitative and quantitative analysis. It offers reliable mass detection over a broad m/z range, rapid switching between ionization modes, and seamless integration with Agilent LC modules, making it well-suited for reaction monitoring, purity assessment, and identification of small molecules in complex mixtures.

The Next Gen 300+  is a compact, automated flash chromatography system for rapid purification of synthetic compounds. It offers precise gradient control, high‑sensitivity UV/visible detection, and automated fraction collection, enabling efficient separation and cleanup of reaction mixtures with minimal user intervention. Uses predictive method development built into PeakTrak software to quickly optimize methods based on the target peak rather than doing multiple TLC plates

The CombiFlash RF is an automated flash chromatography system for rapid, reliable purification of synthetic compounds. It combines programmable gradients, integrated UV/visible detection, and automated fraction collection to efficiently separate complex reaction mixtures and streamline purification workflows. Operates at flow rates typically between 1 to 200 mL/min (depending on the specific configuration) and pressures up to 150 to 200 psi, making it highly effective for both normal and reversed-phase chromatography.

The ACCQPrep HP150 is a preparative HPLC system for high-efficiency purification with flow rates up to 150 mL/min and pressures up to 6,000 psi. It features an intuitive touchscreen interface, built-in software for method development and fraction collection, and flexible detection options including UV and optional ELSD. Engineered for reliability and ease of use, the ACCQPrep HP150 streamlines scale-up from analytical to preparative separations in research and production environments.

The CombiFlash EZ Prep is a hybrid chromatography system that seamlessly combines flash and preparative HPLC in a single, compact platform. It features an intuitive touchscreen interface, automated method development, and versatile detection options to simplify purification workflows from milligram to gram scale. Designed for flexibility and efficiency, the EZ Prep accelerates compound isolation while reducing manual intervention and method transfer challenges.

The Biotage Initiator+ is a microwave synthesizer designed for fast, reproducible chemical reactions with precise temperature and pressure control. It supports a wide range of reaction types and solvents, enabling efficient method development and scale-up from small discovery-scale to larger preparative runs. With intuitive software and robust safety features, the Initiator+ streamlines workflow in medicinal, organic, and materials chemistry laboratories.

The Labconco FreeZone 4.5 L Benchtop Lyophilizer is a compact, laboratory-scale freeze dryer designed for efficient moisture removal from small to medium sample volumes.  Featuring a 4.5-liter ice capacity, it utilizes the intuitive Lyo-Works OS and a 5" color touchscreen for real-time monitoring of vacuum and temperature levels.

The ozone generator produces ozone (O₃) on demand by passing pure oxygen or ambient air through a high-voltage electrical discharge. It used to conduct chemical reactions such as cleaving carbon-carbon double bonds to form alcohols, aldehydes, ketones, or carboxylic acids depending on the chosen workup.

The Liberty Blue 2.0 is an automated microwave peptide synthesizer from CEM Corporation that speeds up Solid Phase Peptide Synthesis (SPPS) using specialized microwave heating, achieving reaction cycles of just 4 minutes per amino acid. It also offers high-throughput accessories that allow users to queue up to 12 syntheses.

The Bruker 400 MHz is a high-field nuclear magnetic resonance (NMR) spectrometer used for structural analysis of small molecules, biomolecules, and materials. Operating at a proton frequency of 400 MHz, it provides high-resolution 1D and 2D NMR spectra, supporting a wide range of experiments (e.g., proton, carbon, and heteronuclear NMR). The NMR facility provides MDSC staff access to a 400 MHz instrument equipped with a sample changer adjacent to MDSC lab space on the 12th floor of MRB IV. In addition, MDSC staff have access to other state-of-the-art NMR spectroscopic equipment along with expert consultation and collaboration (see: NMR Facility).