Polygenic Variation Underlying Neutrophil Counts Modifies the Penetrance of Duffy-Null Neutropenia.
Shelley JP, Shi M, Bastarache L, Chung CP, Mosley JD.
Am J Hematol. 2025 Nov 20. doi: 10.1002/ajh.70144. Online ahead of print.
PMID: 41267342 No abstract available.
No abstract available
Keywords: Duffy‐null phenotype; electronic health records; neutropenia; polygenic scores.
Impact of distinct neurotransmitter release modes on neuronal signaling.
Zhang KJ, Monteggia LM, Kavalali ET.
Mol Psychiatry. 2025 Nov 26. doi: 10.1038/s41380-025-03373-7. Online ahead of print.
PMID: 41299061 Review.
Abstract
Neuronal communication is governed by a diverse repertoire of neurotransmitter release modes, each with distinct molecular machinery and functional roles. Beyond rapid, high-fidelity synchronous release, asynchronous release supports sustained neurotransmitter output, while spontaneous, action-potential-independent release plays a critical role in synaptic development, homeostasis, and plasticity. Complementing these forms of release, slow neurotransmission mediated by monoamines and neuropeptides acts over longer timescales to shape network-wide activity. This review explores the unique mechanisms of each mode, highlighting compelling evidence that spontaneous and evoked release are functionally segregated through separate vesicle pools and distinct postsynaptic receptors. We also examine the molecular complexity and debated physiological roles of asynchronous release, particularly at excitatory synapses, and the specialized machinery of neuromodulatory systems. A comprehensive understanding of these varied release mechanisms is fundamental to neuroscience and opens novel therapeutic avenues. Targeting the unique molecular components of each release mode offers a promising strategy for developing more precise treatments for neurological and psychiatric disorders.
Clonal hematopoiesis activates pro-calcific pathways in macrophages and promotes aortic valve stenosis.
Abplanalp WT, Raddatz MA, Schuhmacher B, Mas-Peiro S, Zuriaga MA, Matesanz N, Fuster JJ, Pershad Y, Vlasschaert C, Silver AJ, Farber-Eger EH, Xu Y, Wells QS, Shahidi D, Fatima S, Yang X, Boruah AA, Ware A, Merten M, von Scheidt M, John D, Shumliakivska M, Muhly-Reinholz M, Vasa-Nicotera M, Guenter S, Savona MR, Lindman BR, Dimmeler S, Bick AG, Zeiher AM.
J Clin Invest. 2025 Nov 18:e171634. doi: 10.1172/JCI171634. Online ahead of print.
PMID: 41252200 Free article.
Human level information extraction from clinical reports with finetuned language models.
Liu L, Lian L, Hao Y, Pace A, Kim E, Homsi N, Pershad Y, Lai L, Gracie T, Kishtagari A, Carroll PR, Bick AG, Odisho AY, Chung M, Yala A.
Sci Rep. 2025 Nov 24. doi: 10.1038/s41598-025-28767-z. Online ahead of print.
PMID: 41286063 Free article.
Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity.
Uzay B, Zhang KJ, Monteggia LM, Kavalali ET.
Mol Psychiatry. 2025 Dec 6. doi: 10.1038/s41380-025-03374-6. Online ahead of print.
PMID: 41353489