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Next-generation, high-speed mass spectrometry imaging!

The rapifleX enables spatially resolved molecular mapping of

The School of Medicine Basic Sciences Mass Spectrometry Research Center is pleased to announce the addition of the Bruker rapifleX MALDI TissueTyper, a next-generation, high-speed mass spectrometry imaging platform.

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Announcing the rapifleX MALDI TissueTyper

High-speed mass spectrometry imaging instrument.

The School of Medicine Basic Sciences Mass Spectrometry Research Center is pleased to announce the addition of the Bruker rapifleX MALDI TissueTyper, a next-generation, high-speed mass spectrometry imaging platform. The rapifleX enables spatially resolved molecular mapping of tissues, characterizing both small and large molecules and delivering acquisition rates up to 20 times faster than traditional MALDI-TOF systems. This increased speed and sensitivity will accelerate biomarker discovery, drug distribution studies, lipidomics, proteomics, and multimodal imaging projects while improving throughput for shared users. “The instrument will be integrated into our service offerings, consultation, and hands-on training programs,” said Jeff Spraggins, MSRC director. Investigators interested in feasibility studies, method development, or collaborative imaging proposals are invited to contact the Center to discuss sample preparation, scheduling, and data analysis support for ongoing translational studies.

 

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Jeff Spraggins, Director MSRC

Jeff Spraggins, MSRC Director

“The instrument will be integrated into our service offerings, consultation, and hands-on training programs.” Jeff Spraggins, Mass Spectrometry Research Center Director

About the rapiflex MALDI TissueTyper

Bruker’s market leading MALDI-TOF system

The rapifleX® MALDI Imaging solution is designed to work up to 20 times faster than traditional MALDI-TOF systems, to meet the increasing requirements of tissue imaging or high-throughput primary screening. The adaptable ion optics and class leading laser technology provide the best data quality, regardless of the acquisition mode or mass range. The unprecedented 10 kHz speed and ion source robustness, the wide dynamic range, higher specificity and resolution, all contribute to the detailed characterization of biologically and clinically relevant lipids, peptides and proteins, raising customer MALDI-TOF/TOF expectations for applications such as:
• MALDI Imaging
• MALDI PharmaPulse® high-throughput screening
• In-depth protein characterization

State of the art technology meets advanced informatics

The rapifleX® combines state-of-the-art technology with advanced informatics into a system that gives you speed, robustness, versatility and confidence. The platform offers a complete characterization system with unprecedented speed of analysis and performance.
Speed - highest throughput provides 5-20 times increase in speed
Robustness - User removable ion source for easy cleaning, designed for maximum uptime in 24/7 operations

rapiflex MADLI Tissuetyper for MALDI Imaging

Features and Benefits and Applications

Learn more about Bruker rapifleX features, benefits and applications!

  • Features

    With speed in mind, we designed the heart of the rapifleX® MALDI Imaging solution to work up to 20 times faster than traditional MALDI-TOF systems, to meet the increasing requirements of tissue imaging or high-throughput primary screening. The adaptable ion optics and class leading laser technology provide the best data quality, regardless of the acquisition mode or mass range.

  • Benefits

    The rapifleX® combines state-of-the-art technology with advanced informatics into a system that gives you speed, robustness, versatility and confidence. The platform offers a complete characterization system with unprecedented speed of analysis and performance.
    Speed - highest throughput provides 5-20 times increase in speed
    Robustness - User removable ion source for easy cleaning, designed for maximum uptime in 24/7 operations
    Confidence
    • Ion optics adapt to application
    • No compromise, maximum resolution for full molecular weight range
    • Maximized sensitivity for MS and MS/MS analysis
    • MS/MS mass range for large peptides such as glycopeptides, di/trisulfide peptides and difficult non-tryptic peptides
    • Superior resolution for high selectivity in complex mixtures
    • Supreme precursor ion selection for confidence in MS/MS data quality
    • High dynamic range
    True pixels – the smartbeam 3D laser features a mode which leads to true squared pixels, harnessing more tissue and ultimately increasing sensitivity.

  • Applications

    MALDI provides single charged ions and fragment ions of molecules that are difficult to analyze using ESI. Non-tryptic peptides can be well analyzed by MALDI MS/MS. Spectra that are otherwise difficult to analyze and inspect can be easily interpreted, such as MS/MS spectra of glycopeptides or disulfide/trisulfide linked peptides. Top-Down spectra of proteins as large as intact antibodies can be automatically interpreted.