School Of Medicine Basic Sciences

Stomach Disorders Vanderbilt School of Medicine basic science researchers study stomach (gastric) cancer by uncovering the molecular and cellular mechanisms that drive tumor initiation, progression, and treatment resistance. Work spans cancer genetics and epigenetics, oncogenic signaling, metabolism, and interactions with the tumor microenvironment and immune system. Many labs use patient-derived… Read More

Spinal cord research Spinal cord and traumatic brain injuries impact millions of people worldwide. These injuries cause neuronal loss and the formation of scar tissue, which is believed to block the regrowth of axons-thin nerve fibers that carry electrical signals. As a result, recovery is limited, often leading to lasting… Read More

Lung Disease Worldwide, chronic respiratory diseases (CRDs) affect hundreds of millions, with COPD and asthma being major burdens, causing millions of deaths annually, driven largely by smoking and air pollution, though age-standardized rates for many CRDs have dropped, absolute numbers rise due to population growth, and pneumonia remains a leading… Read More

  Spinal cord research Spinal cord and traumatic brain injuries impact millions of people worldwide. These injuries cause neuronal loss and the formation of scar tissue, which is believed to block the regrowth of axons-thin nerve fibers that carry electrical signals. As a result, recovery is limited, often leading to… Read More

Kidney Disease Vanderbilt School of Medicine’s Basic Sciences investigators study kidney cancer and kidney disease from molecules to patients. Teams link genomics, epigenetics, and metabolism to clear cell renal cell carcinoma initiation, therapy resistance, and tumor-immune microenvironment. Researchers build organoid, CRISPR, and mouse models to test pathways and identify drug… Read More

Heart Disease Vanderbilt University School of Medicine Basic Sciences researchers are investigating the heart at its foundations, from the molecular signals that control contraction and rhythm to the genetic and cellular pathways that drive atherosclerosis, inflammation, and heart failure. This bench-level insight fuels the next generation of diagnostics and therapies,… Read More

Gallbladder Disease Research Vanderbilt School of Medicine’s Basic Sciences researchers study gallbladder disease by probing the fundamental biology behind gallstone formation and biliary inflammation. Work commonly integrates cell and animal models with human biospecimens. Investigators explore genetic and environmental risk factors, including diet and the gut-liver-biliary axis, and apply modern… Read More

  Breast Cancer research Breast cancer occurs when cells in the breast mutate and grow uncontrollably, forming tumors in ducts or lobules. It is the second most common cancer in U.S. women, with a 90% five-year survival rate due to advances in treatment.  School of Medicine Basic Sciences Breast Cancer… Read More

The School of Medicine Basic Sciences is a remarkable community dedicated to advancing the study of human biology, health, and disease. In addition to the award-winning faculty, postdocs, and students who are at the forefront of our cutting-edge research, a large part of our school’s success can be attributed to… Read More

National Cancer Institute molecular biologist André Nussenzweig delivered a School of Medicine Basic Sciences Apex Lecture on Dec. 15 about genome stability in mitotic and post-mitotic cells. Read More