Vanderbilt Basic Sciences

Vanderbilt researchers have developed an active machine learning approach to predict the effects of tumor variants of unknown significance, or VUS, on sensitivity to chemotherapy. VUS, mutated bits of DNA with unknown impacts on cancer risk, are constantly being identified. The growing number of rare VUS makes it imperative for… Read More

In Grapevine, Arkansas students spent more than two hours on the school bus every day for years. Local scientist Billy Hudson saw that time as an opportunity to create a “magic” school bus with internet and computers where students could spend time learning. Now, more than a decade later, Hudson… Read More

Researchers at Vanderbilt University Medical Center have discovered a potential new target in the fight against colorectal cancer, the nation’s third most common malignancy and, next to lung cancer, the second leading cancer killer. This month in the journal Gastroenterology, R. Daniel Beauchamp, MD, Anna Means, PhD,… Read More

New research from Vanderbilt investigators suggests that clinicians should take a deeper dive into distinguishing EGFR mutations when prescribing targeted therapies for non-small-cell lung cancers. EGFR exon 19 deletion mutations are the most common EGFR mutations in patients with lung cancer. However, the term “exon 19 deletion” is a catch-all… Read More

The bacterium Clostridioides difficile (C. difficile), which causes severe diarrhea and an estimated 400,000 infections annually in the United States, may be a previously unrecognized contributor to colorectal cancer. The findings from human colon cancer specimens, culturing, and mouse models were reported last month by researchers at Johns Hopkins… Read More

Alyssa Hasty, Cornelius Vanderbilt Professor of Molecular Physiology and Biophysics, specializes in immunometabolism, specifically on the role that the immune system plays in obesity and metabolic disease. Recent work from her lab explored the changes in immune cell populations in fat during obesity, weight loss, and weight cycling. The work,… Read More

A Vanderbilt laboratory is investigating the sequence of events necessary for the differentiation of stem cells into heart cells—a key step in embryonic development. Postdoctoral fellow Loic Fort and Louise B. McGavock Professor and Chair of Cell and Developmental Biology Ian Macara published their most recent discoveries on this topic… Read More

Margaret Axelrod, PhD, Rachel Brown, PhD, and Simone Herzberg, aspiring physician-scientists in Vanderbilt University’s Medical Scientist Training Program (MSTP), are among this year’s recipients of highly competitive P.E.O. Scholar Awards. Recipients of the $20,000 awards from P.E.O. International, a philanthropic organization based in Des Moines,… Read More

Jim Cassat, MD, PhD, associate professor of Pediatrics, Pathology, Microbiology and Immunology, and Biomedical Engineering, has received a three-year, $750,000 award from the G. Harold and Leila Y. Mathers Foundation to support research exploring the interplay between bone homeostasis and infectious disease. The Mathers… Read More

Vanderbilt University has named John Kuriyan, one of the world’s leading structural biologists, as its next dean of the School of Medicine Basic Sciences, C. Cybele Raver, provost and vice chancellor for academic affairs, announced today. Kuriyan’s appointment, effective Jan. 1, 2023, will advance the university’s… Read More