Adrian Olivares
Department of Biochemistry
Vanderbilt Institute of Chemical Biology (VICB)
Two fundamental questions my lab aims to address are: how does the cell use mechanical forces to drive biochemical processes across lipid bilayers and how does the nucleus sense and transform mechanical force into biochemically meaningful signals that influence cellular development and function? In particular, we aim to create new methods to visualize and manipulate force transduction pathways that span the nuclear envelope.
Two fundamental questions my lab aims to address are: how does the cell use mechanical forces to drive biochemical processes across lipid bilayers and how does the nucleus sense and transform mechanical force into biochemically meaningful signals that influence cellular development and function? In particular, we aim to create new methods to visualize and manipulate force transduction pathways that span the nuclear envelope.
Keywords: Single molecule force spectroscopy , Optical tweezers , Nuclear envelope , Mechanotransduction , LINC complex , AAA+ molecular chaperones
Research Area: Epithelial Biology , Gene Regulation , Cell Cycle, DNA Repair, and Chromosome Biology , Immunology , Chemical Biology , Molecular Pathology