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Bih-Hwa Shieh

Department of Pharmacology
Neuroscience Graduate Program (NGP)


We study the regulation of rhodopsin endocytosis in Drosophila photoreceptors. We investigate the real-time trafficking using transgenic flies expressing GFP or mCherry tagged rhodopsin or arrestin. We believe that insights into light-regulated rhodopsin endocytosis will further better understanding of GPCR trafficking in vivo.

We study the regulation of rhodopsin endocytosis in Drosophila photoreceptors. We investigate the real-time trafficking using transgenic flies expressing GFP or mCherry tagged rhodopsin or arrestin. We believe that insights into light-regulated rhodopsin endocytosis will further better understanding of GPCR trafficking in vivo.

Keywords: endocytosis , GPCR , rhodopsin , trafficking , Genetics , Drosophila

Research Area: Cell Signaling , Visual Sciences , Developmental Neuroscience