Brandt Eichman
Department of Biological Sciences
Department of Biochemistry
Vanderbilt-Ingram Cancer Center (VICC)
Vanderbilt Institute of Chemical Biology (VICB)
Vanderbilt Center for Structural Biology (CSB)
Molecular Biophysics Training Program
Training Program in Molecular Toxicology
Research in the Eichman laboratory uses X-ray crystallography and other high-resolution structural and biochemical approaches to investigate the molecular mechanisms of DNA repair and replication machines. Current work focuses on base excision repair of bacterial genotoxins and interstrand crosslinks by DNA glycosylases, repair of stalled replication forks by structure-specific DNA translocases, and priming of DNA synthesis during eukaryotic replication.
Research in the Eichman laboratory uses X-ray crystallography and other high-resolution structural and biochemical approaches to investigate the molecular mechanisms of DNA repair and replication machines. Current work focuses on base excision repair of bacterial genotoxins and interstrand crosslinks by DNA glycosylases, repair of stalled replication forks by structure-specific DNA translocases, and priming of DNA synthesis during eukaryotic replication.
Keywords: DNA repair , DNA damage , DNA replication , structural biology , X-ray crystallography , genome maintenance
Research Area: Structural Biology , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Biophysics , Chemical Biology