Brian Bachmann
Department of Chemistry
Department of Biochemistry
Department of Pharmacology
Vanderbilt Institute of Chemical Biology (VICB)
The Vanderbilt Laboratory for Biosynthetic Studies (Bachmann, P.I.) studies and harnesses the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds and revolutionize how molecules are synthesized. By studying pathways and enzymes involved in secondary metabolism, we create new biochemical knowledge, and apply it toward the generation of new bioactive molecules. Our precision-medicine drug discovery subgroup uses a single cell chemical biology paradigm on patient-derived cells to drive the discovery of secondary metabolites as cures for cancer.
The Vanderbilt Laboratory for Biosynthetic Studies (Bachmann, P.I.) studies and harnesses the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds and revolutionize how molecules are synthesized. By studying pathways and enzymes involved in secondary metabolism, we create new biochemical knowledge, and apply it toward the generation of new bioactive molecules. Our precision-medicine drug discovery subgroup uses a single cell chemical biology paradigm on patient-derived cells to drive the discovery of secondary metabolites as cures for cancer.
Keywords: Drug Discovery , Synthetic Biology , Enzymology , Natural Products , Cancer , Precision Medicine
Research Area: Drug Design , Cancer Biology , Chemical Biology , Cell Signaling , Evolution