Deborah Lannigan
Department of Pathology, Microbiology and Immunology (PMI)
Department of Cell and Developmental Biology (CDB)
Department of Biomedical Engineering (BME)
Program in Cancer Biology
Vanderbilt Institute of Chemical Biology (VICB)
Vanderbilt-Ingram Cancer Center (VICC)
We are interested in understanding how signal transduction pathways maintain function during homeostasis and how these processes are disrupted in various disease etiologies, which include breast cancer, infection and chemotherapy-induced cardiac toxicity. To study these questions we employ a variety of techniques, which include modern molecular biology and biochemistry, enzyme kinetics, novel assay development, high throughput screening, drug development, quantitative microscopy, various animal models, novel patient-derived explant cultures, patient-derived xenografts and bioinformatics.
We are interested in understanding how signal transduction pathways maintain function during homeostasis and how these processes are disrupted in various disease etiologies, which include breast cancer, infection and chemotherapy-induced cardiac toxicity. To study these questions we employ a variety of techniques, which include modern molecular biology and biochemistry, enzyme kinetics, novel assay development, high throughput screening, drug development, quantitative microscopy, various animal models, novel patient-derived explant cultures, patient-derived xenografts and bioinformatics.
Keywords: Drug Development , Breast Cancer , Mammary Gland Development , Intracellular Pathogens , Chemotherapy-Induced Cardiac Toxicity , Gene Regulation
Research Area: Drug Design , Gene Regulation , Immunology , Cancer Biology , Cancer Immunology , Cell Signaling