Jason MacGurn
Department of Cell and Developmental Biology (CDB)
Vanderbilt-Ingram Cancer Center (VICC)
Epithelial Biology Center (EBC)
We are broadly interested in understanding how eukaryotic cells regulate membrane trafficking and protein degradation decisions and how these pathways are dysregulated in disease states. We investigate these regulatory pathways using biochemistry, proteomics, and live cell imaging in yeast and mammalian cells with the long-term goal of harnessing the intrinsic protein degradation machinery of eukaryotic cells as a therapeutic strategy for treatment of disease.
We are broadly interested in understanding how eukaryotic cells regulate membrane trafficking and protein degradation decisions and how these pathways are dysregulated in disease states. We investigate these regulatory pathways using biochemistry, proteomics, and live cell imaging in yeast and mammalian cells with the long-term goal of harnessing the intrinsic protein degradation machinery of eukaryotic cells as a therapeutic strategy for treatment of disease.
Keywords: membrane trafficking , cell signaling , ubiquitin biology
Research Area: Imaging , Epithelial Biology , Cancer Biology , Cell Signaling , Developmental Biology , Proteomics/Metabolomics