Jeremy Goettel
Vanderbilt Digestive Diseases Research Center (VDDRC)
Vanderbilt Institute for Infection, Immunology and Inflammation (VI4)
Vanderbilt Center for Mucosal Inflammation and Cancer (CMIC)
Program in Cancer Biology
Our lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis.
Our lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis.
Keywords: IBD , Mucosal Immunity , Cancer , T cells , Microbiome
Research Area: Host-Pathogen Interactions , Immunology , Cancer Biology , Cancer Immunology , Molecular Pathology